Guanine nucleotide-binding protein G(o) subunit alpha
1_MGCTL 6_ SAEER 11_ AALER 16_ SKAIE 21_ KNLKE 26_ DGISA 31_ AKDVK 36_ LLLLG 41_ AGESG 46_ KSTIV 51_ KQMKI 56_ IHEDG 61_ FSGED 66_ VKQYK 71_ PVVYS 76_ NTIQS 81_ LAAIV 86_ RAMDT 91_ LGIEY 96_ GDKER 101_ KADAK 106_ MVCDV 111_ VSRME 116_ DTEPF 121_ SAELL 126_ SAMMR 131_ LWGDS 136_ GIQEC 141_ FNRSR 146_ EYQLN 151_ DSAKY 156_ YLDSL 161_ DRIGA 166_ ADYQP 171_ TEQDI 176_ LRTRV 181_ KTTGI 186_ VETHF 191_ TFKNL 196_ HFRLF 201_ DVGGQ 206_ RSERK 211_ KWIHC 216_ FEDVT 221_ AIIFC 226_ VALSG 231_ YDQVL 236_ HEDET 241_ TNRMH 246_ ESLML 251_ FDSIC 256_ NNKFF 261_ IDTSI 266_ ILFLN 271_ KKDLF 276_ GEKIK 281_ KSPLT 286_ ICFPE 291_ YTGPN 296_ TYEDA 301_ AAYIQ 306_ AQFES 311_ KNRSP 316_ NKEIY 321_ CHMTC 326_ ATDTN 331_ NIQVV 336_ FDAVT 341_ DIIIA 346_NNLRG
1: Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades (PubMed:29925951, PubMed:33408414). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase (By similarity). Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity)