SPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted protein acidic and rich in cysteine)
1_MRAWI 6_ FFLLC 11_ LAGRA 16_ LAAPQ 21_ QEALP 26_ DETEV 31_ VEETV 36_ AEVTE 41_ VSVGA 46_ NPVQV 51_ EVGEF 56_ DDGAE 61_ ETEEE 66_ VVAEN 71_ PCQNH 76_ HCKHG 81_ KVCEL 86_ DENNT 91_ PMCVC 96_ QDPTS 101_ CPAPI 106_ GEFEK 111_ VCSND 116_ NKTFD 121_ SSCHF 126_ FATKC 131_ TLEGT 136_ KKGHK 141_ LHLDY 146_ IGPCK 151_ YIPPC 156_ LDSEL 161_ TEFPL 166_ RMRDW 171_ LKNVL 176_ VTLYE 181_ RDEDN 186_ NLLTE 191_ KQKLR 196_ VKKIH 201_ ENEKR 206_ LEAGD 211_ HPVEL 216_ LARDF 221_ EKNYN 226_ MYIFP 231_ VHWQF 236_ GQLDQ 241_ HPIDG 246_ YLSHT 251_ ELAPL 256_ RAPLI 261_ PMEHC 266_ TTRFF 271_ ETCDL 276_ DNDKY 281_ IALDE 286_ WAGCF 291_ GIKQK 296_DIDKD
1: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity