Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)
1_MDAIK 6_ KKMQM 11_ LKLDK 16_ ENALD 21_ RAEQA 26_ EADKK 31_ AAEDR 36_ SKQLE 41_ DELVS 46_ LQKKL 51_ KGTED 56_ ELDKY 61_ SEALK 66_ DAQEK 71_ LELAE 76_ KKATD 81_ AEADV 86_ ASLNR 91_ RIQLV 96_ EEELD 101_ RAQER 106_ LATAL 111_ QKLEE 116_ AEKAA 121_ DESER 126_ GMKVI 131_ ESRAQ 136_ KDEEK 141_ MEIQE 146_ IQLKE 151_ AKHIA 156_ EDADR 161_ KYEEV 166_ ARKLV 171_ IIESD 176_ LERAE 181_ ERAEL 186_ SEGKC 191_ AELEE 196_ ELKTV 201_ TNNLK 206_ SLEAQ 211_ AEKYS 216_ QKEDR 221_ YEEEI 226_ KVLSD 231_ KLKEA 236_ ETRAE 241_ FAERS 246_ VTKLE 251_ KSIDD 256_ LEDEL 261_ YAQKL 266_ KYKAI 271_ SEELD 276_HALND
1: Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments