Gene name: CD7

Uniprot entry:

P09564

Protein names:

T-cell antigen CD7 (GP40) (T-cell leukemia antigen) (T-cell surface antigen Leu-9) (TP41) (CD antigen CD7)

Protein sequence:

1_MAGPP 6_ RLLLL 11_ PLLLA 16_ LARGL 21_ PGALA 26_ AQEVQ 31_ QSPHC 36_ TTVPV 41_ GASVN 46_ ITCST 51_ SGGLR 56_ GIYLR 61_ QLGPQ 66_ PQDII 71_ YYEDG 76_ VVPTT 81_ DRRFR 86_ GRIDF 91_ SGSQD 96_ NLTIT 101_ MHRLQ 106_ LSDTG 111_ TYTCQ 116_ AITEV 121_ NVYGS 126_ GTLVL 131_ VTEEQ 136_ SQGWH 141_ RCSDA 146_ PPRAS 151_ ALPAP 156_ PTGSA 161_ LPDPQ 166_ TASAL 171_ PDPPA 176_ ASALP 181_ AALAV 186_ ISFLL 191_ GLGLG 196_ VACVL 201_ ARTQI 206_ KKLCS 211_ WRDKN 216_ SAACV 221_ VYEDM 226_ SHSRC 231_NTLSS

Protein annotations

Protein functions:

1: Transmembrane glycoprotein expressed by T-cells and natural killer (NK) cells and their precursors (PubMed:7506726). Plays a costimulatory role in T-cell activation upon binding to its ligand K12/SECTM1 (PubMed:10652336). In turn, mediates the production of cytokines such as IL-2 (PubMed:1709867). On resting NK-cells, CD7 activation results in a significant induction of interferon-gamma levels (PubMed:7506726)