Macrophage colony-stimulating factor 1 (CSF-1) (M-CSF) (MCSF) (Lanimostim) [Cleaved into: Processed macrophage colony-stimulating factor 1]
1_MTAPG 6_ AAGRC 11_ PPTTW 16_ LGSLL 21_ LLVCL 26_ LASRS 31_ ITEEV 36_ SEYCS 41_ HMIGS 46_ GHLQS 51_ LQRLI 56_ DSQME 61_ TSCQI 66_ TFEFV 71_ DQEQL 76_ KDPVC 81_ YLKKA 86_ FLLVQ 91_ DIMED 96_ TMRFR 101_ DNTPN 106_ AIAIV 111_ QLQEL 116_ SLRLK 121_ SCFTK 126_ DYEEH 131_ DKACV 136_ RTFYE 141_ TPLQL 146_ LEKVK 151_ NVFNE 156_ TKNLL 161_ DKDWN 166_ IFSKN 171_ CNNSF 176_ AECSS 181_ QDVVT 186_ KPDCN 191_ CLYPK 196_ AIPSS 201_ DPASV 206_ SPHQP 211_ LAPSM 216_ APVAG 221_ LTWED 226_ SEGTE 231_ GSSLL 236_ PGEQP 241_ LHTVD 246_ PGSAK 251_ QRPPR 256_ STCQS 261_ FEPPE 266_ TPVVK 271_ DSTIG 276_ GSPQP 281_ RPSVG 286_ AFNPG 291_ MEDIL 296_ DSAMG 301_ TNWVP 306_ EEASG 311_ EASEI 316_ PVPQG 321_ TELSP 326_ SRPGG 331_ GSMQT 336_ EPARP 341_ SNFLS 346_ ASSPL 351_ PASAK 356_ GQQPA 361_ DVTGT 366_ ALPRV 371_ GPVRP 376_ TGQDW 381_ NHTPQ 386_ KTDHP 391_ SALLR 396_ DPPEP 401_ GSPRI 406_ SSLRP 411_ QGLSN 416_ PSTLS 421_ AQPQL 426_ SRSHS 431_ SGSVL 436_ PLGEL 441_ EGRRS 446_ TRDRR 451_ SPAEP 456_ EGGPA 461_ SEGAA 466_ RPLPR 471_ FNSVP 476_ LTDTG 481_ HERQS 486_ EGSFS 491_ PQLQE 496_ SVFHL 501_ LVPSV 506_ ILVLL 511_ AVGGL 516_ LFYRW 521_ RRRSH 526_ QEPQR 531_ ADSPL 536_ EQPEG 541_ SPLTQ 546_DDRQV
1: Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance