Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
1_MRLPG 6_ AMPAL 11_ ALKGE 16_ LLLLS 21_ LLLLL 26_ EPQIS 31_ QGLVV 36_ TPPGP 41_ ELVLN 46_ VSSTF 51_ VLTCS 56_ GSAPV 61_ VWERM 66_ SQEPP 71_ QEMAK 76_ AQDGT 81_ FSSVL 86_ TLTNL 91_ TGLDT 96_ GEYFC 101_ THNDS 106_ RGLET 111_ DERKR 116_ LYIFV 121_ PDPTV 126_ GFLPN 131_ DAEEL 136_ FIFLT 141_ EITEI 146_ TIPCR 151_ VTDPQ 156_ LVVTL 161_ HEKKG 166_ DVALP 171_ VPYDH 176_ QRGFS 181_ GIFED 186_ RSYIC 191_ KTTIG 196_ DREVD 201_ SDAYY 206_ VYRLQ 211_ VSSIN 216_ VSVNA 221_ VQTVV 226_ RQGEN 231_ ITLMC 236_ IVIGN 241_ EVVNF 246_ EWTYP 251_ RKESG 256_ RLVEP 261_ VTDFL 266_ LDMPY 271_ HIRSI 276_ LHIPS 281_ AELED 286_ SGTYT 291_ CNVTE 296_ SVNDH 301_ QDEKA 306_ INITV 311_ VESGY 316_ VRLLG 321_ EVGTL 326_ QFAEL 331_ HRSRT 336_ LQVVF 341_ EAYPP 346_ PTVLW 351_ FKDNR 356_ TLGDS 361_ SAGEI 366_ ALSTR 371_ NVSET 376_ RYVSE 381_ LTLVR 386_ VKVAE 391_ AGHYT 396_ MRAFH 401_ EDAEV 406_ QLSFQ 411_ LQINV 416_ PVRVL 421_ ELSES 426_ HPDSG 431_ EQTVR 436_ CRGRG 441_ MPQPN 446_ IIWSA 451_ CRDLK 456_ RCPRE 461_ LPPTL 466_ LGNSS 471_ EEESQ 476_ LETNV 481_ TYWEE 486_ EQEFE 491_ VVSTL 496_ RLQHV 501_ DRPLS 506_ VRCTL 511_ RNAVG 516_ QDTQE 521_ VIVVP 526_ HSLPF 531_ KVVVI 536_ SAILA 541_ LVVLT 546_ IISLI 551_ ILIML 556_ WQKKP 561_ RYEIR 566_ WKVIE 571_ SVSSD 576_ GHEYI 581_ YVDPM 586_ QLPYD 591_ STWEL 596_ PRDQL 601_ VLGRT 606_ LGSGA 611_ FGQVV 616_ EATAH 621_ GLSHS 626_ QATMK 631_ VAVKM 636_ LKSTA 641_ RSSEK 646_ QALMS 651_ ELKIM 656_ SHLGP 661_ HLNVV 666_ NLLGA 671_ CTKGG 676_ PIYII 681_ TEYCR 686_ YGDLV 691_ DYLHR 696_ NKHTF 701_ LQHHS 706_ DKRRP 711_ PSAEL 716_ YSNAL 721_ PVGLP 726_ LPSHV 731_ SLTGE 736_ SDGGY 741_ MDMSK 746_ DESVD 751_ YVPML 756_ DMKGD 761_ VKYAD 766_ IESSN 771_ YMAPY 776_ DNYVP 781_ SAPER 786_ TCRAT 791_ LINES 796_ PVLSY 801_ MDLVG 806_ FSYQV 811_ ANGME 816_ FLASK 821_ NCVHR 826_ DLAAR 831_ NVLIC 836_ EGKLV 841_ KICDF 846_ GLARD 851_ IMRDS 856_ NYISK 861_ GSTFL 866_ PLKWM 871_ APESI 876_ FNSLY 881_ TTLSD 886_ VWSFG 891_ ILLWE 896_ IFTLG 901_ GTPYP 906_ ELPMN 911_ EQFYN 916_ AIKRG 921_ YRMAQ 926_ PAHAS 931_ DEIYE 936_ IMQKC 941_ WEEKF 946_ EIRPP 951_ FSQLV 956_ LLLER 961_ LLGEG 966_ YKKKY 971_ QQVDE 976_ EFLRS 981_ DHPAI 986_ LRSQA 991_ RLPGF 996_ HGLRS 1001_ PLDTS 1006_ SVLYT 1011_ AVQPN 1016_ EGDND 1021_ YIIPL 1026_ PDPKP 1031_ EVADE 1036_ GPLEG 1041_ SPSLA 1046_ SSTLN 1051_ EVNTS 1056_ STISC 1061_ DSPLE 1066_ PQDEP 1071_ EPEPQ 1076_ LELQV 1081_ EPEPE 1086_ LEQLP 1091_ DSGCP 1096_ APRAE 1101_AEDSF
1: Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFD -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PLCG1, PIK3R1, PTPN11, RASA1/GAP, CBL, SHC1 and NCK1. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to the activation of the AKT1 signaling pathway. Phosphorylation of SHC1, or of the C-terminus of PTPN11, creates a binding site for GRB2, resulting in the activation of HRAS, RAF1 and down-stream MAP kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation and activation of SRC family kinases. Promotes phosphorylation of PDCD6IP/ALIX and STAM. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor