Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
1_MSKSE 6_ SPKEP 11_ EQLRK 16_ LFIGG 21_ LSFET 26_ TDESL 31_ RSHFE 36_ QWGTL 41_ TDCVV 46_ MRDPN 51_ TKRSR 56_ GFGFV 61_ TYATV 66_ EEVDA 71_ AMNAR 76_ PHKVD 81_ GRVVE 86_ PKRAV 91_ SREDS 96_ QRPGA 101_ HLTVK 106_ KIFVG 111_ GIKED 116_ TEEHH 121_ LRDYF 126_ EQYGK 131_ IEVIE 136_ IMTDR 141_ GSGKK 146_ RGFAF 151_ VTFDD 156_ HDSVD 161_ KIVIQ 166_ KYHTV 171_ NGHNC 176_ EVRKA 181_ LSKQE 186_ MASAS 191_ SSQRG 196_ RSGSG 201_ NFGGG 206_ RGGGF 211_ GGNDN 216_ FGRGG 221_ NFSGR 226_ GGFGG 231_ SRGGG 236_ GYGGS 241_ GDGYN 246_ GFGND 251_ GGYGG 256_ GGPGY 261_ SGGSR 266_ GYGSG 271_ GQGYG 276_ NQGSG 281_ YGGSG 286_ SYDSY 291_ NNGGG 296_ GGFGG 301_ GSGSN 306_ FGGGG 311_ SYNDF 316_ GNYNN 321_ QSSNF 326_ GPMKG 331_ GNFGG 336_ RSSGP 341_ YGGGG 346_ QYFAK 351_ PRNQG 356_ GYGGS 361_ SSSSS 366_YGSGR
1: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233)
2: (Microbial infection) May play a role in HCV RNA replication
3: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis