Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr)
1_MGCVF 6_ CKKLE 11_ PVATA 16_ KEDAG 21_ LEGDF 26_ RSYGA 31_ ADHYG 36_ PDPTK 41_ ARPAS 46_ SFAHI 51_ PNYSN 56_ FSSQA 61_ INPGF 66_ LDSGT 71_ IRGVS 76_ GIGVT 81_ LFIAL 86_ YDYEA 91_ RTEDD 96_ LTFTK 101_ GEKFH 106_ ILNNT 111_ EGDWW 116_ EARSL 121_ SSGKT 126_ GCIPS 131_ NYVAP 136_ VDSIQ 141_ AEEWY 146_ FGKIG 151_ RKDAE 156_ RQLLS 161_ PGNPQ 166_ GAFLI 171_ RESET 176_ TKGAY 181_ SLSIR 186_ DWDQT 191_ RGDHV 196_ KHYKI 201_ RKLDM 206_ GGYYI 211_ TTRVQ 216_ FNSVQ 221_ ELVQH 226_ YMEVN 231_ DGLCN 236_ LLIAP 241_ CTIMK 246_ PQTLG 251_ LAKDA 256_ WEISR 261_ SSITL 266_ ERRLG 271_ TGCFG 276_ DVWLG 281_ TWNGS 286_ TKVAV 291_ KTLKP 296_ GTMSP 301_ KAFLE 306_ EAQVM 311_ KLLRH 316_ DKLVQ 321_ LYAVV 326_ SEEPI 331_ YIVTE 336_ FMCHG 341_ SLLDF 346_ LKNPE 351_ GQDLR 356_ LPQLV 361_ DMAAQ 366_ VAEGM 371_ AYMER 376_ MNYIH 381_ RDLRA 386_ ANILV 391_ GERLA 396_ CKIAD 401_ FGLAR 406_ LIKDD 411_ EYNPC 416_ QGSKF 421_ PIKWT 426_ APEAA 431_ LFGRF 436_ TIKSD 441_ VWSFG 446_ ILLTE 451_ LITKG 456_ RIPYP 461_ GMNKR 466_ EVLEQ 471_ VEQGY 476_ HMPCP 481_ PGCPA 486_ SLYEA 491_ MEQTW 496_ RLDPE 501_ ERPTF 506_ EYLQS 511_ FLEDY 516_ FTSAE 521_PQYQP
1: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity)