Lactase/phlorizin hydrolase (Lactase/glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Glycosylceramidase (EC 3.2.1.62) (Phlorizin hydrolase)]
1_MELSW 6_ HVVFI 11_ ALLSF 16_ SCWGS 21_ DWESD 26_ RNFIS 31_ TAGPL 36_ TNDLL 41_ HNLSG 46_ LLGDQ 51_ SSNFV 56_ AGDKD 61_ MYVCH 66_ QPLPT 71_ FLPEY 76_ FSSLH 81_ ASQIT 86_ HYKVF 91_ LSWAQ 96_ LLPAG 101_ STQNP 106_ DEKTV 111_ QCYRR 116_ LLKAL 121_ KTARL 126_ QPMVI 131_ LHHQT 136_ LPAST 141_ LRRTE 146_ AFADL 151_ FADYA 156_ TFAFH 161_ SFGDL 166_ VGIWF 171_ TFSDL 176_ EEVIK 181_ ELPHQ 186_ ESRAS 191_ QLQTL 196_ SDAHR 201_ KAYEI 206_ YHESY 211_ AFQGG 216_ KLSVV 221_ LRAED 226_ IPELL 231_ LEPPI 236_ SALAQ 241_ DTVDF 246_ LSLDL 251_ SYECQ 256_ NEASL 261_ RQKLS 266_ KLQTI 271_ EPKVK 276_ VFIFN 281_ LKLPD 286_ CPSTM 291_ KNPAS 296_ LLFSL 301_ FEAIN 306_ KDQVL 311_ TIGFD 316_ INEFL 321_ SCSSS 326_ SKKSM 331_ SCSLT 336_ GSLAL 341_ QPDQQ 346_ QDHET 351_ TDSSP 356_ ASAYQ 361_ RIWEA 366_ FANQS 371_ RAERD 376_ AFLQD 381_ TFPEG 386_ FLWGA 391_ STGAF 396_ NVEGG 401_ WAEGG 406_ RGVSI 411_ WDPRR 416_ PLNTT 421_ EGQAT 426_ LEVAS 431_ DSYHK 436_ VASDV 441_ ALLCG 446_ LRAQV 451_ YKFSI 456_ SWSRI 461_ FPMGH 466_ GSSPS 471_ LPGVA 476_ YYNKL 481_ IDRLQ 486_ DAGIE 491_ PMATL 496_ FHWDL 501_ PQALQ 506_ DHGGW 511_ QNESV 516_ VDAFL 521_ DYAAF 526_ CFSTF 531_ GDRVK 536_ LWVTF 541_ HEPWV 546_ MSYAG 551_ YGTGQ 556_ HPPGI 561_ SDPGV 566_ ASFKV 571_ AHLVL 576_ KAHAR 581_ TWHHY 586_ NSHHR 591_ PQQQG 596_ HVGIV 601_ LNSDW 606_ AEPLS 611_ PERPE 616_ DLRAS 621_ ERFLH 626_ FMLGW 631_ FAHPV 636_ FVDGD 641_ YPATL 646_ RTQIQ 651_ QMNRQ 656_ CSHPV 661_ AQLPE 666_ FTEAE 671_ KQLLK 676_ GSADF 681_ LGLSH 686_ YTSRL 691_ ISNAP 696_ QNTCI 701_ PSYDT 706_ IGGFS 711_ QHVNH 716_ VWPQT 721_ SSSWI 726_ RVVPW 731_ GIRRL 736_ LQFVS 741_ LEYTR 746_ GKVPI 751_ YLAGN 756_ GMPIG 761_ ESENL 766_ FDDSL 771_ RVDYF 776_ NQYIN 781_ EVLKA 786_ IKEDS 791_ VDVRS 796_ YIARS 801_ LIDGF 806_ EGPSG 811_ YSQRF 816_ GLHHV 821_ NFSDS 826_ SKSRT 831_ PRKSA 836_ YFFTS 841_ IIEKN 846_ GFLTK 851_ GAKRL 856_ LPPNT 861_ VNLPS 866_ KVRAF 871_ TFPSE 876_ VPSKA 881_ KVVWE 886_ KFSSQ 891_ PKFER 896_ DLFYH 901_ GTFRD 906_ DFLWG 911_ VSSSA 916_ YQIEG 921_ AWDAD 926_ GKGPS 931_ IWDNF 936_ THTPG 941_ SNVKD 946_ NATGD 951_ IACDS 956_ YHQLD 961_ ADLNM 966_ LRALK 971_ VKAYR 976_ FSISW 981_ SRIFP 986_ TGRNS 991_ SINSH 996_ GVDYY 1001_ NRLIN 1006_ GLVAS 1011_ NIFPM 1016_ VTLFH 1021_ WDLPQ 1026_ ALQDI 1031_ GGWEN 1036_ PALID 1041_ LFDSY 1046_ ADFCF 1051_ QTFGD 1056_ RVKFW 1061_ MTFNE 1066_ PMYLA 1071_ WLGYG 1076_ SGEFP 1081_ PGVKD 1086_ PGWAP 1091_ YRIAH 1096_ AVIKA 1101_ HARVY 1106_ HTYDE 1111_ KYRQE 1116_ QKGVI 1121_ SLSLS 1126_ THWAE 1131_ PKSPG 1136_ VPRDV 1141_ EAADR 1146_ MLQFS 1151_ LGWFA 1156_ HPIFR 1161_ NGDYP 1166_ DTMKW 1171_ KVGNR 1176_ SELQH 1181_ LATSR 1186_ LPSFT 1191_ EEEKR 1196_ FIRAT 1201_ ADVFC 1206_ LNTYY 1211_ SRIVQ 1216_ HKTPR 1221_ LNPPS 1226_ YEDDQ 1231_ EMAEE 1236_ EDPSW 1241_ PSTAM 1246_ NRAAP 1251_ WGTRR 1256_ LLNWI 1261_ KEEYG 1266_ DIPIY 1271_ ITENG 1276_ VGLTN 1281_ PNTED 1286_ TDRIF 1291_ YHKTY 1296_ INEAL 1301_ KAYRL 1306_ DGIDL 1311_ RGYVA 1316_ WSLMD 1321_ NFEWL 1326_ NGYTV 1331_ KFGLY 1336_ HVDFN 1341_ NTNRP 1346_ RTARA 1351_ SARYY 1356_ TEVIT 1361_ NNGMP 1366_ LARED 1371_ EFLYG 1376_ RFPEG 1381_ FIWSA 1386_ ASAAY 1391_ QIEGA 1396_ WRADG 1401_ KGLSI 1406_ WDTFS 1411_ HTPLR 1416_ VENDA 1421_ IGDVA 1426_ CDSYH 1431_ KIAED 1436_ LVTLQ 1441_ NLGVS 1446_ HYRFS 1451_ ISWSR 1456_ ILPDG 1461_ TTRYI 1466_ NEAGL 1471_ NYYVR 1476_ LIDTL 1481_ LAASI 1486_ QPQVT 1491_ IYHWD 1496_ LPQTL 1501_ QDVGG 1506_ WENET 1511_ IVQRF 1516_ KEYAD 1521_ VLFQR 1526_ LGDKV 1531_ KFWIT 1536_ LNEPF 1541_ VIAYQ 1546_ GYGYG 1551_ TAAPG 1556_ VSNRP 1561_ GTAPY 1566_ IVGHN 1571_ LIKAH 1576_ AEAWH 1581_ LYNDV 1586_ YRASQ 1591_ GGVIS 1596_ ITISS 1601_ DWAEP 1606_ RDPSN 1611_ QEDVE 1616_ AARRY 1621_ VQFMG 1626_ GWFAH 1631_ PIFKN 1636_ GDYNE 1641_ VMKTR 1646_ IRDRS 1651_ LAAGL 1656_ NKSRL 1661_ PEFTE 1666_ SEKRR 1671_ INGTY 1676_ DFFGF 1681_ NHYTT 1686_ VLAYN 1691_ LNYAT 1696_ AISSF 1701_ DADRG 1706_ VASIA 1711_ DRSWP 1716_ DSGSF 1721_ WLKMT 1726_ PFGFR 1731_ RILNW 1736_ LKEEY 1741_ NDPPI 1746_ YVTEN 1751_ GVSQR 1756_ EETDL 1761_ NDTAR 1766_ IYYLR 1771_ TYINE 1776_ ALKAV 1781_ QDKVD 1786_ LRGYT 1791_ VWSAM 1796_ DNFEW 1801_ ATGFS 1806_ ERFGL 1811_ HFVNY 1816_ SDPSL 1821_ PRIPK 1826_ ASAKF 1831_ YASVV 1836_ RCNGF 1841_ PDPAT 1846_ GPHAC 1851_ LHQPD 1856_ AGPTI 1861_ SPVRQ 1866_ EEVQF 1871_ LGLML 1876_ GTTEA 1881_ QTALY 1886_ VLFSL 1891_ VLLGV 1896_ CGLAF 1901_ LSYKY 1906_ CKRSK 1911_ QGKTQ 1916_ RSQQE 1921_LSPVS
1: Broad specificity glycosidase of the intestinal brush border membrane that hydrolyzes lactose, the main sugar in mammalian milk, to produce D-glucose and D-galactose (PubMed:12594539, PubMed:16400612, PubMed:3929764, PubMed:9762914). The mature protein is composed of two domains that catalyze the hydrolysis of beta-glucopyranosides and beta-galactopyranosides, with a preference for hydrophilic aglycones (in lactose and cellobiose) for one domain and hydrophobic aglycones (in phlorizin and glycosylceramides) for the other (PubMed:12594539, PubMed:3929764, PubMed:9762914)