Interferon-induced protein with tetratricopeptide repeats 2 (IFIT-2) (ISG-54 K) (Interferon-induced 54 kDa protein) (IFI-54K) (P54)
1_MSENN 6_ KNSLE 11_ SSLRQ 16_ LKCHF 21_ TWNLM 26_ EGENS 31_ LDDFE 36_ DKVFY 41_ RTEFQ 46_ NREFK 51_ ATMCN 56_ LLAYL 61_ KHLKG 66_ QNEAA 71_ LECLR 76_ KAEEL 81_ IQQEH 86_ ADQAE 91_ IRSLV 96_ TWGNY 101_ AWVYY 106_ HMGRL 111_ SDVQI 116_ YVDKV 121_ KHVCE 126_ KFSSP 131_ YRIES 136_ PELDC 141_ EEGWT 146_ RLKCG 151_ GNQNE 156_ RAKVC 161_ FEKAL 166_ EKKPK 171_ NPEFT 176_ SGLAI 181_ ASYRL 186_ DNWPP 191_ SQNAI 196_ DPLRQ 201_ AIRLN 206_ PDNQY 211_ LKVLL 216_ ALKLH 221_ KMREE 226_ GEEEG 231_ EGEKL 236_ VEEAL 241_ EKAPG 246_ VTDVL 251_ RSAAK 256_ FYRRK 261_ DEPDK 266_ AIELL 271_ KKALE 276_ YIPNN 281_ AYLHC 286_ QIGCC 291_ YRAKV 296_ FQVMN 301_ LRENG 306_ MYGKR 311_ KLLEL 316_ IGHAV 321_ AHLKK 326_ ADEAN 331_ DNLFR 336_ VCSIL 341_ ASLHA 346_ LADQY 351_ EDAEY 356_ YFQKE 361_ FSKEL 366_ TPVAK 371_ QLLHL 376_ RYGNF 381_ QLYQM 386_ KCEDK 391_ AIHHF 396_ IEGVK 401_ INQKS 406_ REKEK 411_ MKDKL 416_ QKIAK 421_ MRLSK 426_ NGADS 431_ EALHV 436_ LAFLQ 441_ ELNEK 446_ MQQAD 451_ EDSER 456_ GLESG 461_ SLIPS 466_ASSWN
1: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis