Interferon-induced protein with tetratricopeptide repeats 1 (IFIT-1) (Interferon-induced 56 kDa protein) (IFI-56K) (P56)
1_MSTNG 6_ DDHQV 11_ KDSLE 16_ QLRCH 21_ FTWEL 26_ SIDDD 31_ EMPDL 36_ ENRVL 41_ DQIEF 46_ LDTKY 51_ SVGIH 56_ NLLAY 61_ VKHLK 66_ GQNEE 71_ ALKSL 76_ KEAEN 81_ LMQEE 86_ HDNQA 91_ NVRSL 96_ VTWGN 101_ FAWMY 106_ YHMGR 111_ LAEAQ 116_ TYLDK 121_ VENIC 126_ KKLSN 131_ PFRYR 136_ MECPE 141_ IDCEE 146_ GWALL 151_ KCGGK 156_ NYERA 161_ KACFE 166_ KVLEV 171_ DPENP 176_ ESSAG 181_ YAISA 186_ YRLDG 191_ FKLAT 196_ KNHKP 201_ FSLLP 206_ LRQAV 211_ RLNPD 216_ NGYIK 221_ VLLAL 226_ KLQDE 231_ GQEAE 236_ GEKYI 241_ EEALA 246_ NMSSQ 251_ TYVFR 256_ YAAKF 261_ YRRKG 266_ SVDKA 271_ LELLK 276_ KALQE 281_ TPTSV 286_ LLHHQ 291_ IGLCY 296_ KAQMI 301_ QIKEA 306_ TKGQP 311_ RGQNR 316_ EKLDK 321_ MIRSA 326_ IFHFE 331_ SAVEK 336_ KPTFE 341_ VAHLD 346_ LARMY 351_ IEAGN 356_ HRKAE 361_ ENFQK 366_ LLCMK 371_ PVVEE 376_ TMQDI 381_ HFHYG 386_ RFQEF 391_ QKKSD 396_ VNAII 401_ HYLKA 406_ IKIEQ 411_ ASLTR 416_ DKSIN 421_ SLKKL 426_ VLRKL 431_ RRKAL 436_ DLESL 441_ SLLGF 446_ VYKLE 451_ GNMNE 456_ ALEYY 461_ ERALR 466_ LAADF 471_ENSVR
1: Plays a key role in the innate immune response as part of an interferon-dependent multiprotein complex, recognizing and sequestering viral RNAs that lack host-specific 2'-O-methylation at their 5' cap. By distinguishing these RNAs from host mRNAs, inhibits their translation by competing with the translation initiation factor eIF4E (PubMed:21642987, PubMed:27240734, PubMed:39009378, PubMed:23334420, PubMed:28251928, PubMed:36285486). Could also prevent viral replication through its interaction with DNA replication origin-binding protein E1 of several viruses. Causes the translocation of E1 from the nucleus to the cytoplasm and can also inhibit its helicase activity in vitro (PubMed:19008854, PubMed:21976647). Exhibits antiviral activity against many viruses from the Flaviviridae (West Nile virus, Dengue virus, hepatitis C virus), Coronaviridae (human 229E coronavirus, SARS-CoV-2 and SARS-CoV), Poxviridae (vaccinia virus) and Togaviridae (Sindbis virus) families (PubMed:19008854, PubMed:21976647, PubMed:28251928, PubMed:36285486)