Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE)
1_MELRP 6_ WLLWV 11_ VAATG 16_ TLVLL 21_ AADAQ 26_ GQKVF 31_ TNTWA 36_ VRIPG 41_ GPAVA 46_ NSVAR 51_ KHGFL 56_ NLGQI 61_ FGDYY 66_ HFWHR 71_ GVTKR 76_ SLSPH 81_ RPRHS 86_ RLQRE 91_ PQVQW 96_ LEQQV 101_ AKRRT 106_ KRDVY 111_ QEPTD 116_ PKFPQ 121_ QWYLS 126_ GVTQR 131_ DLNVK 136_ AAWAQ 141_ GYTGH 146_ GIVVS 151_ ILDDG 156_ IEKNH 161_ PDLAG 166_ NYDPG 171_ ASFDV 176_ NDQDP 181_ DPQPR 186_ YTQMN 191_ DNRHG 196_ TRCAG 201_ EVAAV 206_ ANNGV 211_ CGVGV 216_ AYNAR 221_ IGGVR 226_ MLDGE 231_ VTDAV 236_ EARSL 241_ GLNPN 246_ HIHIY 251_ SASWG 256_ PEDDG 261_ KTVDG 266_ PARLA 271_ EEAFF 276_ RGVSQ 281_ GRGGL 286_ GSIFV 291_ WASGN 296_ GGREH 301_ DSCNC 306_ DGYTN 311_ SIYTL 316_ SISSA 321_ TQFGN 326_ VPWYS 331_ EACSS 336_ TLATT 341_ YSSGN 346_ QNEKQ 351_ IVTTD 356_ LRQKC 361_ TESHT 366_ GTSAS 371_ APLAA 376_ GIIAL 381_ TLEAN 386_ KNLTW 391_ RDMQH 396_ LVVQT 401_ SKPAH 406_ LNAND 411_ WATNG 416_ VGRKV 421_ SHSYG 426_ YGLLD 431_ AGAMV 436_ ALAQN 441_ WTTVA 446_ PQRKC 451_ IIDIL 456_ TEPKD 461_ IGKRL 466_ EVRKT 471_ VTACL 476_ GEPNH 481_ ITRLE 486_ HAQAR 491_ LTLSY 496_ NRRGD 501_ LAIHL 506_ VSPMG 511_ TRSTL 516_ LAARP 521_ HDYSA 526_ DGFND 531_ WAFMT 536_ THSWD 541_ EDPSG 546_ EWVLE 551_ IENTS 556_ EANNY 561_ GTLTK 566_ FTLVL 571_ YGTAP 576_ EGLPV 581_ PPESS 586_ GCKTL 591_ TSSQA 596_ CVVCE 601_ EGFSL 606_ HQKSC 611_ VQHCP 616_ PGFAP 621_ QVLDT 626_ HYSTE 631_ NDVET 636_ IRASV 641_ CAPCH 646_ ASCAT 651_ CQGPA 656_ LTDCL 661_ SCPSH 666_ ASLDP 671_ VEQTC 676_ SRQSQ 681_ SSRES 686_ PPQQQ 691_ PPRLP 696_ PEVEA 701_ GQRLR 706_ AGLLP 711_ SHLPE 716_ VVAGL 721_ SCAFI 726_ VLVFV 731_ TVFLV 736_ LQLRS 741_ GFSFR 746_ GVKVY 751_ TMDRG 756_ LISYK 761_ GLPPE 766_ AWQEE 771_ CPSDS 776_ EEDEG 781_ RGERT 786_AFIKD
1: Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:11799113, PubMed:1629222, PubMed:1713771, PubMed:2251280, PubMed:24666235, PubMed:25974265, PubMed:7592877, PubMed:7690548, PubMed:9130696). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (PubMed:7737999). Converts through proteolytic cleavage the non-functional Brain natriuretic factor prohormone into its active hormone BNP(1-32) (PubMed:20489134, PubMed:21763278). By mediating processing of accessory subunit ATP6AP1/Ac45 of the V-ATPase, regulates the acidification of dense-core secretory granules in islets of Langerhans cells (By similarity)
2: (Microbial infection) Cleaves and activates diphtheria toxin DT
3: (Microbial infection) Cleaves and activates anthrax toxin protective antigen (PA)
4: (Microbial infection) Cleaves and activates HIV-1 virus Envelope glycoprotein gp160
5: (Microbial infection) Required for H7N1 and H5N1 influenza virus infection probably by cleaving hemagglutinin
6: (Microbial infection) Able to cleave S.pneumoniae serine-rich repeat protein PsrP
7: (Microbial infection) Facilitates human coronaviruses EMC and SARS-CoV-2 infections by proteolytically cleaving the spike protein at the monobasic S1/S2 cleavage site. This cleavage is essential for spike protein-mediated cell-cell fusion and entry into human lung cells
8: (Microbial infection) Facilitates mumps virus infection by proteolytically cleaving the viral fusion protein F