Peroxisomal coenzyme A diphosphatase NUDT7 (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 7) (Nudix motif 7)
1_MSRLG 6_ LPEEP 11_ VRNSL 16_ LDDAK 21_ ARLRK 26_ YDIGG 31_ KYSHL 36_ PYNKY 41_ SVLLP 46_ LVAKE 51_ GKLHL 56_ LFTVR 61_ SEKLR 66_ RAPGE 71_ VCFPG 76_ GKRDP 81_ TDMDD 86_ AATAL 91_ REAQE 96_ EVGLR 101_ PHQVE 106_ VVCCL 111_ VPCLI 116_ DTDTL 121_ ITPFV 126_ GLIDH 131_ NFQAQ 136_ PNPAE 141_ VKDVF 146_ LVPLA 151_ YFLHP 156_ QVHDQ 161_ HYVTR 166_ LGHRF 171_ INHIF 176_ EYTNP 181_ EDGVT 186_ YQIKG 191_ MTANL 196_ AVLVA 201_ FIILE 206_ KKPTF 211_ EVQFN 216_ LNDVL 221_ ASSEE 226_ LFLKV 231_HKKAT
1: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies (By similarity). Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs (By similarity). Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester (By similarity). May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand (By similarity). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity)