Ras-related protein Rab-40A-like (Ras-like GTPase)
1_MSAPG 6_ SPDQA 11_ YDFLL 16_ KFLLV 21_ GDRDV 26_ GKSEI 31_ LESLQ 36_ DGTAE 41_ SPYSH 46_ LGGID 51_ YKTTT 56_ ILLDG 61_ QRVKL 66_ KLWDT 71_ SGQGR 76_ FCTIF 81_ RSYSR 86_ GAQGV 91_ ILVYD 96_ IANRW 101_ SFEGM 106_ DRWIK 111_ KIEEH 116_ APGVP 121_ KILVG 126_ NRLHL 131_ AFKRQ 136_ VPREQ 141_ AQAYA 146_ ERLGV 151_ TFFEV 156_ SPLCN 161_ FNIIE 166_ SFTEL 171_ ARIVL 176_ LRHRL 181_ NWLGR 186_ PSKVL 191_ SLQDL 196_ CCRTI 201_ VSCTP 206_ VHLVD 211_ KLPLP 216_ IALRS 221_ HLKSF 226_ SMAKG 231_ LNARM 236_ MRGLS 241_ YSLTT 246_ SSTHK 251_ RSSLC 256_ KVKIV 261_ CPPQS 266_ PPKNC 271_TRNSC
1: May act as substrate-recognition component of the ECS(RAB40) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity)