Histone H2A.Z (H2A/z)
1_MAGGK 6_ AGKDS 11_ GKAKT 16_ KAVSR 21_ SQRAG 26_ LQFPV 31_ GRIHR 36_ HLKSR 41_ TTSHG 46_ RVGAT 51_ AAVYS 56_ AAILE 61_ YLTAE 66_ VLELA 71_ GNASK 76_ DLKVK 81_ RITPR 86_ HLQLA 91_ IRGDE 96_ ELDSL 101_ IKATI 106_ AGGGV 111_ IPHIH 116_ KSLIG 121_KKGQQ
1: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division