Histone H2B type F-M (Histone H2B.s) (H2B/s)
1_MAAAS 6_ AMAEA 11_ SSETT 16_ SEEGQ 21_ SIQEP 26_ KEANS 31_ TKAQK 36_ QKRRG 41_ CRGSR 46_ RRHAN 51_ RRGDS 56_ FGDSF 61_ TPYFP 66_ RVLKQ 71_ VHQGL 76_ SLSQE 81_ AVSVM 86_ DSMIH 91_ DILDR 96_ IATEA 101_ GQLAH 106_ YTKRV 111_ TITSR 116_ DIQMA 121_ VRLLL 126_ PGKMG 131_ KLAEA 136_ QGTNA 141_ ALRTS 146_LCAIW
1: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling