Wee1-like protein kinase 2 (EC 2.7.10.2) (Wee1-like protein kinase 1B) (Wee1B kinase)
1_MDDKD 6_ IDKEL 11_ RQKLN 16_ FSYCE 21_ ETEIE 26_ GQKKV 31_ EESRE 36_ ASSQT 41_ PEKGE 46_ VQDSE 51_ AKGTP 56_ PWTPL 61_ SNVHE 66_ LDTSS 71_ EKDKE 76_ SPDQI 81_ LRTPV 86_ SHPLK 91_ CPETP 96_ AQPDS 101_ RSKLL 106_ PSDSP 111_ STPKT 116_ MLSRL 121_ VISPT 126_ GKLPS 131_ RGPKH 136_ LKLTP 141_ APLKD 146_ EMTSL 151_ ALVNI 156_ NPFTP 161_ ESYKK 166_ LFLQS 171_ GGKRK 176_ IRGDL 181_ EEAGP 186_ EEGKG 191_ GLPAK 196_ RCVLR 201_ ETNMA 206_ SRYEK 211_ EFLEV 216_ EKIGV 221_ GEFGT 226_ VYKCI 231_ KRLDG 236_ CVYAI 241_ KRSMK 246_ TFTEL 251_ SNENS 256_ ALHEV 261_ YAHAV 266_ LGHHP 271_ HVVRY 276_ YSSWA 281_ EDDHM 286_ IIQNE 291_ YCNGG 296_ SLQAA 301_ ISENT 306_ KSGNH 311_ FEEPK 316_ LKDIL 321_ LQISL 326_ GLNYI 331_ HNSSM 336_ VHLDI 341_ KPSNI 346_ FICHK 351_ MQSES 356_ SGVIE 361_ EVENE 366_ ADWFL 371_ SANVM 376_ YKIGD 381_ LGHAT 386_ SINKP 391_ KVEEG 396_ DSRFL 401_ ANEIL 406_ QEDYR 411_ HLPKA 416_ DIFAL 421_ GLTIA 426_ VAAGA 431_ ESLPT 436_ NGAAW 441_ HHIRK 446_ GNFPD 451_ VPQEL 456_ SESFS 461_ SLLKN 466_ MIQPD 471_ AEQRP 476_ SAAAL 481_ ARNTV 486_ LRPSL 491_ GKTEE 496_ LQQQL 501_ NLEKF 506_ KTATL 511_ ERELR 516_ EAQQA 521_ QSPQG 526_ YTHHG 531_ DTGVS 536_ GTHTG 541_ SRSTK 546_ RLVGG 551_ KSARS 556_ SSFTS 561_GEREP
1: Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II (PubMed:29606300). Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation (By similarity)