Histone H2A-Bbd type 1 (H2A Barr body-deficient) (H2A.B) (H2A.Bbd)
1_MPRRR 6_ RRRGS 11_ SGAGG 16_ RGRTC 21_ SRTVR 26_ AELSF 31_ SVSQV 36_ ERSLR 41_ EGHYA 46_ QRLSR 51_ TAPVY 56_ LAAVI 61_ EYLTA 66_ KVPEL 71_ AGNEA 76_ QNSGE 81_ RNITP 86_ LLLDM 91_ VVHND 96_ RLLST 101_ LFNTT 106_TISQV
1: Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing (PubMed:22795134). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (PubMed:15257289, PubMed:16287874, PubMed:16957777, PubMed:17591702, PubMed:17726088, PubMed:18329190, PubMed:22795134). Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo (PubMed:15257289, PubMed:16957777, PubMed:17591702, PubMed:24336483). They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase (PubMed:17591702, PubMed:24753410). They associate with spliceosome components and are required for mRNA splicing (PubMed:22795134)