Histone H2A-Bbd type 2/3 (H2A Barr body-deficient) (H2A.Bbd)
1_MPRRR 6_ RRRGS 11_ SGAGG 16_ RGRTC 21_ SRTVR 26_ AELSF 31_ SVSQV 36_ ERSLR 41_ EGHYA 46_ QRLSR 51_ TAPVY 56_ LAAVI 61_ EYLTA 66_ KVLEL 71_ AGNEA 76_ QNSGE 81_ RNITP 86_ LLLDM 91_ VVHND 96_ RLLST 101_ LFNTT 106_TISQV
1: Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis