GATA-type zinc finger protein 1 (GATA-like protein 1) (GLP-1)
1_MTEPQ 6_ VGCVA 11_ CPRVH 16_ KEPAQ 21_ VGTPW 26_ PAKPR 31_ SHPRK 36_ RDPTA 41_ LLPRS 46_ LWPAC 51_ QESVT 56_ ALCFL 61_ QETVE 66_ RLGQS 71_ PAQDT 76_ PVLGP 81_ CWDPM 86_ ALGTQ 91_ GRLLL 96_ DRDSK 101_ DTQTR 106_ ISQKG 111_ RRLQP 116_ PGTPS 121_ APPQR 126_ RPRKQ 131_ LNPCR 136_ GTERV 141_ DPGFE 146_ GVTLK 151_ FQIKP 156_ DSSLQ 161_ IIPTY 166_ SLPCS 171_ SRSQE 176_ SPADA 181_ VGGPA 186_ AHPGG 191_ TEAHS 196_ AGSEA 201_ LEPRR 206_ CASCR 211_ TQRTP 216_ LWRDA 221_ EDGTP 226_ LCNAC 231_ GIRYK 236_ KYGTR 241_ CSSCW 246_ LVPRK 251_ NVQPK 256_ RLCGR 261_ CGVSL 266_DPIQE
1: Transcriptional regulator that plays a key role in germ cell development. Determines the oogenic fate by activating key genes for the oogenic program and meiotic prophase entry. Acts downstream of bone morphogenetic protein (BMP) by regulating expression of genes required for the oogenic programs, which are repressed by Polycomb activities in sexually uncommitted germ cells. Regulates expression of STRA8, a central downstream effector for the meiotic program. Acts independently of retinoic acid (RA). In males, not required for germ-cell sex determination, but required to allow the spermatogonia to efficiently accomplish the meiotic prophase