Gene name: OST4

Uniprot entry:

P0C6T2

Protein names:

Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

Protein sequence:

1_MITDV 6_ QLAIF 11_ ANMLG 16_ VSLFL 21_ LVVLY 26_ HYVAV 31_NNPKK

Protein annotations

Protein functions:

1: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Specifically involved in maintaining stability of STT3A-containing OST complexes