Protein SLFN14 [Cleaved into: C-terminally truncated SLFN14 endoribonuclease (EC 3.1.-.-) (Schlafen family member 14)]
1_MESLK 6_ TDTEM 11_ PYPEV 16_ IVDVG 21_ RVIFG 26_ EENRK 31_ KMTNS 36_ CLKRS 41_ ENSRI 46_ IRAIC 51_ ALLNS 56_ GGGVI 61_ KAEID 66_ DKTYS 71_ YQCHG 76_ LGQDL 81_ ETSFQ 86_ KLLPS 91_ GSQKY 96_ LDYMQ 101_ QGHNL 106_ LIFVK 111_ SWSPD 116_ VFSLP 121_ LRICS 126_ LRSNL 131_ YRRDV 136_ TSAIN 141_ LSASS 146_ ALELL 151_ REKGF 156_ RAQRG 161_ RPRVK 166_ KLHPQ 171_ QVLNR 176_ CIQEE 181_ EDMRI 186_ LASEF 191_ FKKDK 196_ LMYKE 201_ KLNFT 206_ ESTHV 211_ EFKRF 216_ TTKKV 221_ IPRIK 226_ EMLPH 231_ YVSAF 236_ ANTQG 241_ GYVLI 246_ GVDDK 251_ SKEVV 256_ GCKWE 261_ KVNPD 266_ LLKKE 271_ IENCI 276_ EKLPT 281_ FHFCC 286_ EKPKV 291_ NFTTK 296_ ILNVY 301_ QKDVL 306_ DGYVC 311_ VIQVE 316_ PFCCV 321_ VFAEA 326_ PDSWI 331_ MKDNS 336_ VTRLT 341_ AEQWV 346_ VMMLD 351_ TQSAP 356_ PSLVT 361_ DYNSC 366_ LISSA 371_ SSARK 376_ SPGYP 381_ IKVHK 386_ FKEAL 391_ QRHLF 396_ PVTQE 401_ EVQFK 406_ PESLC 411_ KKLFS 416_ DHKEL 421_ EGLMK 426_ TLIHP 431_ CSQGI 436_ VIFSR 441_ SWAGD 446_ VGFRK 451_ EQNVL 456_ CDALL 461_ IAVNS 466_ PVVLY 471_ TILID 476_ PNWPG 481_ GLEYA 486_ RNTAH 491_ QLKQK 496_ LQTVG 501_ GYTGK 506_ VCIIP 511_ RLIHL 516_ SSTQS 521_ RPGEI 526_ PLRYP 531_ RSYRL 536_ ADEEE 541_ MEDLL 546_ QALVV 551_ VSLSS 556_ RSLLS 561_ DQMGC 566_ EFFNL 571_ LIMEQ 576_ SQLLS 581_ ESLQK 586_ TRELF 591_ IYCFP 596_ GVRKT 601_ ALAIK 606_ IMEKI 611_ KDLFH 616_ CKPKE 621_ ILYVC 626_ ESDSL 631_ KDFVT 636_ QQTTC 641_ QAVTR 646_ KTFMQ 651_ GEFLK 656_ IKHIV 661_ MDETE 666_ NFCSK 671_ YGNWY 676_ MKAKN 681_ ITHPK 686_ AKGTG 691_ SENLH 696_ HGILW 701_ LFLDP 706_ FQIHH 711_ ADVNG 716_ LPPPS 721_ AQFPR 726_ KTITS 731_ GIHCA 736_ LEIAK 741_ VMKEE 746_ MKRIK 751_ ENPPS 756_ NMSPD 761_ TLALF 766_ SETAY 771_ EEATC 776_ AQALP 781_ GVCET 786_ KTNLT 791_ TEQIA 796_ NYVAR 801_ KCHSL 806_ FQCGY 811_ LPKDI 816_ AILCR 821_ RGEDR 826_ GRYRL 831_ ALLKA 836_ MELIE 841_ THRPS 846_ EVVFS 851_ PATGV 856_ WGSHI 861_ VLDSI 866_ QQFSG 871_ LERTV 876_ VFGLS 881_ PECDQ 886_ SEEFH 891_ KLCFA 896_ SRAIK 901_ HLYLL 906_YEKRA
1: Shows no ribosome-associated and endoribonuclease activities
2: Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed:25996083). May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner (By similarity). Involved in correct maturation of megakaryocytes and especially important for proplatelet extension