Ataxin-1-like (Brother of ataxin-1) (Brother of ATXN1)
1_MKPVH 6_ ERSQE 11_ CLPPK 16_ KRDLP 21_ VTSED 26_ MGRTT 31_ SCSTN 36_ HTPSS 41_ DASEW 46_ SRGVV 51_ VAGQS 56_ QAGAR 61_ VSLGG 66_ DGAEA 71_ ITGLT 76_ VDQYG 81_ MLYKV 86_ AVPPA 91_ TFSPT 96_ GLPSV 101_ VNMSP 106_ LPPTF 111_ NVASS 116_ LIQHP 121_ GIHYP 126_ PLHYA 131_ QLPST 136_ SLQFI 141_ GSPYS 146_ LPYAV 151_ PPNFL 156_ PSPLL 161_ SPSAN 166_ LATSH 171_ LPHFV 176_ PYASL 181_ LAEGA 186_ TPPPQ 191_ APSPA 196_ HSFNK 201_ APSAT 206_ SPSGQ 211_ LPHHS 216_ STQPL 221_ DLAPG 226_ RMPIY 231_ YQMSR 236_ LPAGY 241_ TLHET 246_ PPAGA 251_ SPVLT 256_ PQESQ 261_ SALEA 266_ AAANG 271_ GQRPR 276_ ERNLV 281_ RRESE 286_ ALDSP 291_ NSKGE 296_ GQGLV 301_ PVVEC 306_ VVDGQ 311_ LFSGS 316_ QTPRV 321_ EVAAP 326_ AHRGT 331_ PDTDL 336_ EVQRV 341_ VGALA 346_ SQDYR 351_ VVAAQ 356_ RKEEP 361_ SPLNL 366_ SHHTP 371_ DHQGE 376_ GRGSA 381_ RNPAE 386_ LAEKS 391_ QARGF 396_ YPQSH 401_ QEPVK 406_ HRPLP 411_ KAMVV 416_ ANGNL 421_ VPTGT 426_ DSGLL 431_ PVGSE 436_ ILVAS 441_ SLDVQ 446_ ARATF 451_ PDKEP 456_ TPPPI 461_ TSSHL 466_ PSHFM 471_ KGAII 476_ QLATG 481_ ELKRV 486_ EDLQT 491_ QDFVR 496_ SAEVS 501_ GGLKI 506_ DSSTV 511_ VDIQE 516_ SQWPG 521_ FVMLH 526_ FVVGE 531_ QQSKV 536_ SIEVP 541_ PEHPF 546_ FVYGQ 551_ GWSSC 556_ SPGRT 561_ TQLFS 566_ LPCHR 571_ LQVGD 576_ VCISI 581_ SLQSL 586_ NSNSV 591_ SQASC 596_ APPSQ 601_ LGPPR 606_ ERPER 611_ TVLGS 616_ RELCD 621_ SEGKS 626_ QPAGE 631_ GSRVV 636_ EPSQP 641_ ESGAQ 646_ ACWPA 651_ PSFQR 656_ YSMQG 661_ EEARA 666_ ALLRP 671_ SFIPQ 676_ EVKLS 681_IEGRS
1: Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression (PubMed:21475249). Can suppress ATXN1 cytotoxicity in spinocerebellar ataxia type 1 (SCA1). In concert with CIC and ATXN1, involved in brain development (By similarity)