DNA-directed RNA polymerase II subunit GRINL1A (DNA-directed RNA polymerase II subunit M) (Glutamate receptor-like protein 1A)
1_MCSLP 6_ RGFEP 11_ QAPED 16_ LAQRS 21_ LVELR 26_ EMLKR 31_ QERLL 36_ RNEKF 41_ ICKLP 46_ DKGKK 51_ IFDSF 56_ AKLKA 61_ AIAEC 66_ EEVRR 71_ KSELF 76_ NPVSL 81_ DCKLR 86_ QKAIA 91_ EVDVG 96_ TDKAQ 101_ NSDPI 106_ LDTSS 111_ LVPGC 116_ SSVDN 121_ IKSSQ 126_ TSQNQ 131_ GLGRP 136_ TLEGD 141_ EETSE 146_ VEYTV 151_ NKGPA 156_ SSNRD 161_ RVPPS 166_ SEASE 171_ HHPRH 176_ RVSSQ 181_ AEDTS 186_ SSFDN 191_ LFIDR 196_ LQRIT 201_ IADQG 206_ EQQSE 211_ ENAST 216_ KNLTG 221_ LSSGT 226_ EKKPH 231_ YMEVL 236_ EMRAK 241_ NPVPQ 246_ LRKFK 251_ TNVLP 256_ FRQND 261_ SSSHC 266_ QKSGS 271_ PISSE 276_ ERRRR 281_ DKQHL 286_ DDITA 291_ ARLLP 296_ LHHMP 301_ TQLLS 306_ IEESL 311_ ALQKQ 316_ QKQNY 321_ EEMQA 326_ KLAAQ 331_ KLAER 336_ LNIKM 341_ RSYNP 346_ EGESS 351_ GRYRE 356_ VRDED 361_DDWSS
1: Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II