Chromosome transmission fidelity protein 8 homolog (hCTF8)
1_MVQIV 6_ ISSAR 11_ AGGLA 16_ EWVLM 21_ ELQGE 26_ IEARY 31_ STGLA 36_ GNLLG 41_ DLHYT 46_ TEGIP 51_ VLIVG 56_ HHILY 61_ GKIIH 66_ LEKPF 71_ AVLVK 76_ HTPGD 81_ QDCDE 86_ LGRET 91_ GTRYL 96_ VTALI 101_ KDKIL 106_ FKTRP 111_ KPIIT 116_SVPKK
1: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DSCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression