SLIT-ROBO Rho GTPase-activating protein 2C (SLIT-ROBO Rho GTPase activating protein 2 pseudogene 1)
1_MTSPA 6_ KFKKD 11_ KEIIA 16_ EYDTQ 21_ VKEIR 26_ AQLTE 31_ QMKCL 36_ DQQCE 41_ LRVQL 46_ LQDLQ 51_ DFFRK 56_ KAEIE 61_ MDYSR 66_ NLEKL 71_ AEHFL 76_ AKTRS 81_ TKDQQ 86_ FKKDQ 91_ NVLSP 96_ VNCWN 101_ LLLNQ 106_ VKWES 111_ RDHTT 116_ LSDIY 121_ LNNII 126_ PRFVQ 131_ VSEDS 136_ GRLFK 141_ KSKEV 146_ GQQLQ 151_ DDLMK 156_ VLNEL 161_ YSVMK 166_ TYHMY 171_ NADSI 176_ SAQSK 181_ LKEAE 186_ KQEEK 191_ QIGKS 196_ VKQED 201_ RQTPC 206_ SPDST 211_ ANVRI 216_ EEKHV 221_ RRSSV 226_ KKIEK 231_ MKEKH 236_ QAKYT 241_ ENKLK 246_ AIKAQ 251_ NEYLL 256_ ALEAT 261_ NASVF 266_ KYYIH 271_ DLSDL 276_ IDQCC 281_ DLGYH 286_ ASLNR 291_ ALRTF 296_ LSAEL 301_ NLEQS 306_ KHEGL 311_ DAIEN 316_ AVENL 321_ DATSD 326_ KQRLM 331_ EMYNN 336_ VFCPP 341_ MKFEF 346_ QPHMG 351_ DMASQ 356_ LCAQQ 361_ PVQSE 366_ LVQRC 371_ QQLQS 376_ RLSTL 381_ KIENE 386_ EVKKT 391_ MEATL 396_ QTIQD 401_ IVTVE 406_ DFDVS 411_ DCFQY 416_ SNSME 421_ SVKST 426_ VSETF 431_ MSKPS 436_ IAKRR 441_ ANQQE 446_ TEQFY 451_FTVRE
1: Human-specific protein that acts as a key modifier of cortical connectivity in the human brain (PubMed:22559944, PubMed:27373832, PubMed:34707291). Acts by inhibiting the functions of ancestral paralog SRGAP2/SRGAP2A, a postsynaptic protein that regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:22559944, PubMed:27373832). SRGAP2C is unstable but is able to heterodimerize with SRGAP2/SRGAP2A, thereby reducing SRGAP2/SRGAP2A levels through proteasome-dependent degradation (PubMed:27373832, PubMed:28333212, PubMed:31822692). Inhibition of SRGAP2/SRGAP2A by SRGAP2C leads to an increase in synaptic density and protracted synaptic maturation of both excitatory and inhibitory synapses (PubMed:27373832, PubMed:34707291). Modifies cortical circuit connectivity by increasing the number of local and long-range cortical inputs received by layer 2/3 pyramidal neurons (PubMed:34707291). Also able to increase the probability of sensory-evoked responses by layer 2/3 pyramidal neurons (PubMed:34707291)