Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator DWORF (SERCA regulator DWORF) (Dwarf open reading frame) (DWORF) (Small transmembrane regulator of ion transport 1)
1_MAEKA 6_ GSTFS 11_ HLLVP 16_ ILLLI 21_ GWIVG 26_CIIMI
1: Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity (By similarity). Also enhances the activity of the ATP2A2/SERCA2 ATPase (PubMed:33581112). Does not directly stimulate SERCA pump activity (By similarity). Binds preferentially to the phosphorylated E1 and E2 conformational forms of ATP2A2 which predominate at high Ca(2+) concentrations during the systolic phase of the cardiac cycle (By similarity). Competes with ATP2A2 inhibitor phospholamban (PLN) for binding to ATP2A2 and displaces PLN (PubMed:33581112). Can activate ATP2A2 directly in the absence of PLN (PubMed:33581112). Also enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN) and myoregulin (MRLN) (By similarity)