Calmodulin-3
1_MADQL 6_ TEEQI 11_ AEFKE 16_ AFSLF 21_ DKDGD 26_ GTITT 31_ KELGT 36_ VMRSL 41_ GQNPT 46_ EAELQ 51_ DMINE 56_ VDADG 61_ NGTID 66_ FPEFL 71_ TMMAR 76_ KMKDT 81_ DSEEE 86_ IREAF 91_ RVFDK 96_ DGNGY 101_ ISAAE 106_ LRHVM 111_ TNLGE 116_ KLTDE 121_ EVDEM 126_ IREAD 131_ IDGDG 136_ QVNYE 141_EFVQM
1: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:31454269). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:31454269, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425)
2: (Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity