Secreted Ly-6/uPAR domain-containing protein 2 (Secreted LY6/PLAUR domain-containing protein 2) (Secreted Ly-6/uPAR-related protein 2) (SLURP-2)
1_MQLGT 6_ GLLLA 11_ AVLSL 16_ QLAAA 21_ EAIWC 26_ HQCTG 31_ FGGCS 36_ HGSRC 41_ LRDST 46_ HCVTT 51_ ATRVL 56_ SNTED 61_ LPLVT 66_ KMCHI 71_ GCPDI 76_ PSLGL 81_ GPYVS 86_ IACCQ 91_TSLCN
1: Binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. May regulate keratinocytes proliferation, differentiation and apoptosis. In vitro moderately inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs and strongly these of alpha-4:beta-2-containing nAChRs, modulates alpha-7-containing nAChRs, and inhibits nicotine-induced signaling probably implicating alpha-3:beta-4-containing nAChRs. Proposed to act on alpha-3:beta-2 and alpha-7 nAChRs in an orthosteric, and on mAChRs, such as CHRM1 and CHRM3, in an allosteric manner