Chimeric ERCC6-PGBD3 protein (Chimeric CSB-PGBD3 protein)
1_MPNEG 6_ IPHSS 11_ QTQEQ 16_ DCLQS 21_ QPVSN 26_ NEEMA 31_ IKQES 36_ GGDGE 41_ VEEYL 46_ SFRSV 51_ GDGLS 56_ TSAVG 61_ CASAA 66_ PRRGP 71_ ALLHI 76_ DRHQI 81_ QAVEP 86_ SAQAL 91_ ELQGL 96_ GVDVY 101_ DQDVL 106_ EQGVL 111_ QQVDN 116_ AIHEA 121_ SRASQ 126_ LVDVE 131_ KEYRS 136_ VLDDL 141_ TSCTT 146_ SLRQI 151_ NKIIE 156_ QLSPQ 161_ AATSR 166_ DINRK 171_ LDSVK 176_ RQKYN 181_ KEQQL 186_ KKITA 191_ KQKHL 196_ QAILG 201_ GAEVK 206_ IELDH 211_ ASLEE 216_ DAEPG 221_ PSSLG 226_ SMLMP 231_ VQETA 236_ WEELI 241_ RTGQM 246_ TPFGT 251_ QIPQK 256_ QEKKP 261_ RKIML 266_ NEASG 271_ FEKYL 276_ ADQAK 281_ LSFER 286_ KKQGC 291_ NKRAA 296_ RKAPA 301_ PVTPP 306_ APVQN 311_ KNKPN 316_ KKARV 321_ LSKKE 326_ ERLKK 331_ HIKKL 336_ QKRAL 341_ QFQGK 346_ VGLPK 351_ ARRPW 356_ ESDMR 361_ PEAEG 366_ DSEGE 371_ ESEYF 376_ PTEEE 381_ EEEED 386_ DEVEG 391_ AEADL 396_ SGDGT 401_ DYELK 406_ PLPKG 411_ GKRQK 416_ KVPVQ 421_ EIDDD 426_ FFPSS 431_ GEEAE 436_ AASVG 441_ EGGGG 446_ GRKVG 451_ RYRDD 456_ GDEDY 461_ YKQRL 466_ SPKMP 471_ RTLSL 476_ HEITD 481_ LLETD 486_ DSIEA 491_ SAIVI 496_ QPPEN 501_ ATAPV 506_ SDEES 511_ GDEEG 516_ GTINN 521_ LPGSL 526_ LHTAA 531_ YLIQD 536_ GSDAE 541_ SDSDD 546_ PSYAP 551_ KDDSP 556_ DEVPS 561_ TFTVQ 566_ QPPPS 571_ RRRKM 576_ TKILC 581_ KWKKA 586_ DLTVQ 591_ PVAGR 596_ VTAPP 601_ NDFFT 606_ VMRTP 611_ TEILE 616_ LFLDD 621_ EVIEL 626_ IVKYS 631_ NLYAC 636_ SKGVH 641_ LGLTS 646_ SEFKC 651_ FLGII 656_ FLSGY 661_ VSVPR 666_ RRMFW 671_ EQRTD 676_ VHNVL 681_ VSAAM 686_ RRDRF 691_ ETIFS 696_ NLHVA 701_ DNANL 706_ DPVDK 711_ FSKLR 716_ PLISK 721_ LNERC 726_ MKFVP 731_ NETYF 736_ SFDEF 741_ MVPYF 746_ GRHGC 751_ KQFIR 756_ GKPIR 761_ FGYKF 766_ WCGAT 771_ CLGYI 776_ CWFQP 781_ YQGKN 786_ PNTKH 791_ EEYGV 796_ GASLV 801_ LQFSE 806_ ALTEA 811_ HPGQY 816_ HFVFN 821_ NFFTS 826_ IALLD 831_ KLSSM 836_ GHQAT 841_ GTVRK 846_ DHIDR 851_ VPLES 856_ DVALK 861_ KKERG 866_ TFDYR 871_ IDGKG 876_ NIVCR 881_ WNDNS 886_ VVTVA 891_ SSGAG 896_ IHPLC 901_ LVSRY 906_ SQKLK 911_ KKIQV 916_ QQPNM 921_ IKVYN 926_ QFMGG 931_ VDRAD 936_ ENIDK 941_ YRASI 946_ RGKKW 951_ YSSPL 956_ LFCFE 961_ LVLQN 966_ AWQLH 971_ KTYDE 976_ KPVDF 981_ LEFRR 986_ RVVCH 991_ YLETH 996_ GHPPE 1001_ PGQKG 1006_ RPQKR 1011_ NIDSR 1016_ YDGIN 1021_ HVIVK 1026_ QGKQT 1031_ RCAEC 1036_ HKNTT 1041_ FRCEK 1046_ CDVAL 1051_ HVKCS 1056_VEYHT
1: Involved in repair of DNA damage following UV irradiation, acting either in the absence of ERCC6 or synergistically with ERCC6. Involved in the regulation of gene expression. In the absence of ERCC6, induces the expression of genes characteristic of interferon-like antiviral responses. This response is almost completely suppressed in the presence of ERCC6. In the presence of ERCC6, regulates the expression of genes involved in metabolism regulation, including IGFBP5 and IGFBP7. In vitro binds to PGBD3-related transposable elements, called MER85s; these non-autonomous 140 bp elements are characterized by the presence of PGBD3 terminal inverted repeats and the absence of internal transposase ORF