Notch homolog 2 N-terminal-like protein B
1_MPALR 6_ PALLW 11_ ALLAL 16_ WLCCA 21_ TPAHA 26_ LQCRD 31_ GYEPC 36_ VNEGM 41_ CVTYH 46_ NGTGY 51_ CKCPE 56_ GFLGE 61_ YCQHR 66_ DPCEK 71_ NRCQN 76_ GGTCV 81_ AQAML 86_ GKATC 91_ RCASG 96_ FTGED 101_ CQYST 106_ SHPCF 111_ VSRPC 116_ LNGGT 121_ CHMLS 126_ RDTYE 131_ CTCQV 136_ GFTGK 141_ ECQWT 146_ DACLS 151_ HPCAN 156_ GSTCT 161_ TVANQ 166_ FSCKC 171_ LTGFT 176_ GQKCE 181_ TDVNE 186_ CDIPG 191_ HCQHG 196_ GICLN 201_ LPGSY 206_ QCQCL 211_ QGFTG 216_ QYCDS 221_ LYVPC 226_ APSPC 231_ VNGGT 236_ CRQTG 241_ DFTFE 246_ CNCLP 251_ ETVRR 256_ GTELW 261_ ERDRE 266_VWNGK
1: Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29561261, PubMed:29856954, PubMed:29856955). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954, PubMed:29856955). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954, PubMed:29856955). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (PubMed:29856955)