Notch homolog 2 N-terminal-like protein C
1_MCVTY 6_ HNGTG 11_ YCKCP 16_ EGFLG 21_ EYCQH 26_ RDPCE 31_ KNRCQ 36_ NGGTC 41_ VAQAM 46_ LGKAT 51_ CRCAS 56_ GFTGE 61_ DCQYS 66_ TSHPC 71_ FVSRP 76_ CLNGG 81_ TCHML 86_ SRDTY 91_ ECTCQ 96_ VGFTG 101_ KECQW 106_ TDACL 111_ SHPCA 116_ NGSTC 121_ TTVAN 126_ QFSCK 131_ CLTGF 136_ TGQKC 141_ ETDVN 146_ ECDIP 151_ GHCQH 156_ GGTCL 161_ NLPGS 166_ YQCQC 171_ LQGFT 176_ GQYCD 181_ SLYVP 186_ CAPSP 191_ CVNGG 196_ TCRQT 201_ GDFTF 206_ ECNCL 211_ PETVR 216_ RGTEL 221_ WERDR 226_ EVWNG 231_KEHDE
1: Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29561261, PubMed:29856954, PubMed:29856955). Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production (PubMed:29856954). Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect (PubMed:29856954). Enhances Notch signaling pathway in a non-cell-autonomous manner via direct interaction with NOTCH2 (PubMed:29856954). Also promotes Notch signaling pathway in a cell-autonomous manner through inhibition of cis DLL1-NOTCH2 interactions, which promotes neuronal differentiation (By similarity)