UDP-glucuronosyltransferase 2A1 (UDPGT 2A1) (UGT2A1) (EC 2.4.1.17)
1_MLNNL 6_ LLFSL 11_ QISLI 16_ GTTLG 21_ GNVLI 26_ WPMEG 31_ SHWLN 36_ VKIII 41_ DELIK 46_ KEHNV 51_ TVLVA 56_ SGALF 61_ ITPTS 66_ NPSLT 71_ FEIYK 76_ VPFGK 81_ ERIEG 86_ VIKDF 91_ VLTWL 96_ ENRPS 101_ PSTIW 106_ RFYQE 111_ MAKVI 116_ KDFHM 121_ VSQEI 126_ CDGVL 131_ KNQQL 136_ MAKLK 141_ KSKFE 146_ VLVSD 151_ PVFPC 156_ GDIVA 161_ LKLGI 166_ PFMYS 171_ LRFSP 176_ ASTVE 181_ KHCGK 186_ VPYPP 191_ SYVPA 196_ VLSEL 201_ TDQMS 206_ FTDRI 211_ RNFIS 216_ YHLQD 221_ YMFET 226_ LWKSW 231_ DSYYS 236_ KALGG 241_ LLLCC 246_ PGWSA 251_ VADLG 256_ SLQPL 261_ LPGFK 266_ RFSRL 271_ SLHCS 276_ WDYRL 281_ PAGRP 286_ TTLCE 291_ TMGKA 296_ EIWLI 301_ RTYWD 306_ FEFPR 311_ PYLPN 316_ FEFVG 321_ GLHCK 326_ PAKPL 331_ PKVLW 336_ RYKGK 341_ KPATL 346_ GNNTQ 351_ LFDWI 356_ PQNDL 361_ LGHPK 366_ TKAFI 371_ THGGT 376_ NGIYE 381_ AIYHG 386_ VPMVG 391_ VPMFA 396_ DQPDN 401_ IAHMK 406_ AKGAA 411_ VEVNL 416_ NTMTS 421_ VDLLS 426_ ALRTV 431_ INEPS 436_ YKENA 441_ MRLSR 446_ IHHDQ 451_ PVKPL 456_ DRAVF 461_ WIEFV 466_ MRHKG 471_ AKHLR 476_ VAAHD 481_ LTWFQ 486_ YHSLD 491_ VIGFL 496_ LVCVT 501_ TAIFL 506_ VIQCC 511_ LFSCQ 516_ KFGKI 521_GKKKK
1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:10359671, PubMed:18719240, PubMed:19022937, PubMed:19858781, PubMed:23288867, PubMed:23756265). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:10359671, PubMed:19858781, PubMed:23756265). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone and epitestosterone) and estrogens (estradiol and epiestriol) (PubMed:18719240, PubMed:19022937, PubMed:19858781, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Shows a high affinity to aliphatic odorants such as citronellol as well as olfactory tissue specificity, and therefore may be involved in olfaction (PubMed:10359671). Shows a potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth (PubMed:19858781)