UDP-glucuronosyltransferase 2A2 (UDPGT 2A2) (EC 2.4.1.17)
1_MVSIR 6_ DFTMP 11_ KKFVQ 16_ MLVFN 21_ LTLTE 26_ VVLSG 31_ NVLIW 36_ PTDGS 41_ HWLNI 46_ KIILE 51_ ELIQR 56_ NHNVT 61_ VLASS 66_ ATLFI 71_ NSNPD 76_ SPVNF 81_ EVIPV 86_ SYKKS 91_ NIDSL 96_ IEHMI 101_ MLWID 106_ HRPTP 111_ LTIWA 116_ FYKEL 121_ GKLLD 126_ TFFQI 131_ NIQLC 136_ DGVLK 141_ NPKLM 146_ ARLQK 151_ GGFDV 156_ LVADP 161_ VTICG 166_ DLVAL 171_ KLGIP 176_ FMYTL 181_ RFSPA 186_ STVER 191_ HCGKI 196_ PAPVS 201_ YVPAA 206_ LSELT 211_ DQMTF 216_ GERIK 221_ NTISY 226_ SLQDY 231_ IFQSY 236_ WGEWN 241_ SYYSK 246_ ILGRP 251_ TTLCE 256_ TMGKA 261_ EIWLI 266_ RTYWD 271_ FEFPR 276_ PYLPN 281_ FEFVG 286_ GLHCK 291_ PAKPL 296_ PKEME 301_ EFIQS 306_ SGKNG 311_ VVVFS 316_ LGSMV 321_ KNLTE 326_ EKANL 331_ IASAL 336_ AQIPQ 341_ KVLWR 346_ YKGKK 351_ PATLG 356_ NNTQL 361_ FDWIP 366_ QNDLL 371_ GHPKT 376_ KAFIT 381_ HGGTN 386_ GIYEA 391_ IYHGV 396_ PMVGV 401_ PMFAD 406_ QPDNI 411_ AHMKA 416_ KGAAV 421_ EVNLN 426_ TMTSV 431_ DLLSA 436_ LRTVI 441_ NEPSY 446_ KENAM 451_ RLSRI 456_ HHDQP 461_ VKPLD 466_ RAVFW 471_ IEFVM 476_ RHKGA 481_ KHLRV 486_ AAHDL 491_ TWFQY 496_ HSLDV 501_ IGFLL 506_ VCVTT 511_ AIFLV 516_ IQCCL 521_ FSCQK 526_ FGKIG 531_KKKKR
1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240, PubMed:19858781, PubMed:23288867, PubMed:23756265). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:19858781, PubMed:23756265). Catalyzes the glucuronidation of endogenous estrogen hormone estradiol (PubMed:18719240, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Shows a potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth (PubMed:19858781)