Transcriptional activator GLI3 (GLI3 form of 190 kDa) (GLI3-190) (GLI3 full-length protein) (GLI3FL) [Cleaved into: Transcriptional repressor GLI3R (GLI3 C-terminally truncated form) (GLI3 form of 83 kDa) (GLI3-83)]
1_MEAQS 6_ HSSTT 11_ TEKKK 16_ VENSI 21_ VKCST 26_ RTDVS 31_ EKAVA 36_ SSTTS 41_ NEDES 46_ PGQTY 51_ HRERR 56_ NAITM 61_ QPQNV 66_ QGLSK 71_ VSEEP 76_ STSSD 81_ ERASL 86_ IKKEI 91_ HGSLP 96_ HVAEP 101_ SVPYR 106_ GTVFA 111_ MDPRN 116_ GYMEP 121_ HYHPP 126_ HLFPA 131_ FHPPV 136_ PIDAR 141_ HHEGR 146_ YHYDP 151_ SPIPP 156_ LHMTS 161_ ALSSS 166_ PTYPD 171_ LPFIR 176_ ISPHR 181_ NPTAA 186_ SESPF 191_ SPPHP 196_ YINPY 201_ MDYIR 206_ SLHSS 211_ PSLSM 216_ ISATR 221_ GLSPT 226_ DAPHA 231_ GVSPA 236_ EYYHQ 241_ MALLT 246_ GQRSP 251_ YADII 256_ PSAAT 261_ AGTGA 266_ IHMEY 271_ LHAMD 276_ STRFS 281_ SPRLS 286_ ARPSR 291_ KRTLS 296_ ISPLS 301_ DHSFD 306_ LQTMI 311_ RTSPN 316_ SLVTI 321_ LNNSR 326_ SSSSA 331_ SGSYG 336_ HLSAS 341_ AISPA 346_ LSFTY 351_ SSAPV 356_ SLHMH 361_ QQILS 366_ RQQSL 371_ GSAFG 376_ HSPPL 381_ IHPAP 386_ TFPTQ 391_ RPIPG 396_ IPTVL 401_ NPVQV 406_ SSGPS 411_ ESSQN 416_ KPTSE 421_ SAVSS 426_ TGDPM 431_ HNKRS 436_ KIKPD 441_ EDLPS 446_ PGARG 451_ QQEQP 456_ EGTTL 461_ VKEEG 466_ DKDES 471_ KQEPE 476_ VIYET 481_ NCHWE 486_ GCARE 491_ FDTQE 496_ QLVHH 501_ INNDH 506_ IHGEK 511_ KEFVC 516_ RWLDC 521_ SREQK 526_ PFKAQ 531_ YMLVV 536_ HMRRH 541_ TGEKP 546_ HKCTF 551_ EGCTK 556_ AYSRL 561_ ENLKT 566_ HLRSH 571_ TGEKP 576_ YVCEH 581_ EGCNK 586_ AFSNA 591_ SDRAK 596_ HQNRT 601_ HSNEK 606_ PYVCK 611_ IPGCT 616_ KRYTD 621_ PSSLR 626_ KHVKT 631_ VHGPE 636_ AHVTK 641_ KQRGD 646_ IHPRP 651_ PPPRD 656_ SGSHS 661_ QSRSP 666_ GRPTQ 671_ GALGE 676_ QQDLS 681_ NTTSK 686_ REECL 691_ QVKTV 696_ KAEKP 701_ MTSQP 706_ SPGGQ 711_ SSCSS 716_ QQSPI 721_ SNYSN 726_ SGLEL 731_ PLTDG 736_ GSIGD 741_ LSAID 746_ ETPIM 751_ DSTIS 756_ TATTA 761_ LALQA 766_ RRNPA 771_ GTKWM 776_ EHVKL 781_ ERLKQ 786_ VNGMF 791_ PRLNP 796_ ILPPK 801_ APAVS 806_ PLIGN 811_ GTQSN 816_ NTCSL 821_ GGPMT 826_ LLPGR 831_ SDLSG 836_ VDVTM 841_ LNMLN 846_ RRDSS 851_ ASTIS 856_ SAYLS 861_ SRRSS 866_ GISPC 871_ FSSRR 876_ SSEAS 881_ QAEGR 886_ PQNVS 891_ VADSY 896_ DPIST 901_ DASRR 906_ SSEAS 911_ QSDGL 916_ PSLLS 921_ LTPAQ 926_ QYRLK 931_ AKYAA 936_ ATGGP 941_ PPTPL 946_ PNMER 951_ MSLKT 956_ RLALL 961_ GDALE 966_ PGVAL 971_ PPVHA 976_ PRRCS 981_ DGGAH 986_ GYGRR 991_ HLQPH 996_ DAPGH 1001_ GVRRA 1006_ SDPVR 1011_ TGSEG 1016_ LALPR 1021_ VPRFS 1026_ SLSSC 1031_ NPPAM 1036_ ATSAE 1041_ KRSLV 1046_ LQNYT 1051_ RPEGG 1056_ QSRNF 1061_ HSSPC 1066_ PPSIT 1071_ ENVTL 1076_ ESLTM 1081_ DADAN 1086_ LNDED 1091_ FLPDD 1096_ VVQYL 1101_ NSQNQ 1106_ AGYEQ 1111_ HFPSA 1116_ LPDDS 1121_ KVPHG 1126_ PGDFD 1131_ APGLP 1136_ DSHAG 1141_ QQFHA 1146_ LEQPC 1151_ PEGSK 1156_ TDLPI 1161_ QWNEV 1166_ SSGSA 1171_ DLSSS 1176_ KLKCG 1181_ PRPAV 1186_ PQTRA 1191_ FGFCN 1196_ GMVVH 1201_ PQNPL 1206_ RSGPA 1211_ GGYQT 1216_ LGENS 1221_ NPYGG 1226_ PEHLM 1231_ LHNSP 1236_ GSGTS 1241_ GNAFH 1246_ EQPCK 1251_ APQYG 1256_ NCLNR 1261_ QPVAP 1266_ GALDG 1271_ ACGAG 1276_ IQASK 1281_ LKSTP 1286_ MQGSG 1291_ GQLNF 1296_ GLPVA 1301_ PNESA 1306_ GSMVN 1311_ GMQNQ 1316_ DPVGQ 1321_ GYLAH 1326_ QLLGD 1331_ SMQHP 1336_ GAGRP 1341_ GQQML 1346_ GQISA 1351_ TSHIN 1356_ IYQGP 1361_ ESCLP 1366_ GAHGM 1371_ GSQPS 1376_ SLAVV 1381_ RGYQP 1386_ CASFG 1391_ GSRRQ 1396_ AMPRD 1401_ SLALQ 1406_ SGQLS 1411_ DTSQT 1416_ CRVNG 1421_ IKMEM 1426_ KGQPH 1431_ PLCSN 1436_ LQNYS 1441_ GQFYD 1446_ QTVGF 1451_ SQQDT 1456_ KAGSF 1461_ SISDA 1466_ SCLLQ 1471_ GTSAK 1476_ NSELL 1481_ SPGAN 1486_ QVTST 1491_ VDSLD 1496_ SHDLE 1501_ GVQID 1506_ FDAII 1511_ DDGDH 1516_ SSLMS 1521_ GALSP 1526_ SIIQN 1531_ LSHSS 1536_ SRLTT 1541_ PRASL 1546_ PFPAL 1551_ SMSTT 1556_ NMAIG 1561_ DMSSL 1566_ LTSLA 1571_EESKF
1: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'