Telomere zinc finger-associated protein (TZAP) (Krueppel-related zinc finger protein 3) (hKR3) (Zinc finger and BTB domain-containing protein 48) (Zinc finger protein 855)
1_MDGSF 6_ VQHSV 11_ RVLQE 16_ LNKQR 21_ EKGQY 26_ CDATL 31_ DVGGL 36_ VFKAH 41_ WSVLA 46_ CCSHF 51_ FQSLY 56_ GDGSG 61_ GSVVL 66_ PAGFA 71_ EIFGL 76_ LLDFF 81_ YTGHL 86_ ALTSG 91_ NRDQV 96_ LLAAR 101_ ELRVP 106_ EAVEL 111_ CQSFK 116_ PKTSV 121_ GQAAG 126_ GQSGL 131_ GPPAS 136_ QNVNS 141_ HVKEP 146_ AGLEE 151_ EEVSR 156_ TLGLV 161_ PRDQE 166_ PRGSH 171_ SPQRP 176_ QLHSP 181_ AQSEG 186_ PSSLC 191_ GKLKQ 196_ ALKPC 201_ PLEDK 206_ KPEDC 211_ KVPPR 216_ PLEAE 221_ GAQLQ 226_ GGSNE 231_ WEVVV 236_ QVEDD 241_ GDGDY 246_ MSEPE 251_ AVLTR 256_ RKSNV 261_ IRKPC 266_ AAEPA 271_ LSAGS 276_ LAAEP 281_ AENRK 286_ GTAVP 291_ VECPT 296_ CHKKF 301_ LSKYY 306_ LKVHN 311_ RKHTG 316_ EKPFE 321_ CPKCG 326_ KCYFR 331_ KENLL 336_ EHEAR 341_ NCMNR 346_ SEQVF 351_ TCSVC 356_ QETFR 361_ RRMEL 366_ RVHMV 371_ SHTGE 376_ MPYKC 381_ SSCSQ 386_ QFMQK 391_ KDLQS 396_ HMIKL 401_ HGAPK 406_ PHACP 411_ TCAKC 416_ FLSRT 421_ ELQLH 426_ EAFKH 431_ RGEKL 436_ FVCEE 441_ CGHRA 446_ SSRNG 451_ LQMHI 456_ KAKHR 461_ NERPH 466_ VCEFC 471_ SHAFT 476_ QKANL 481_ NMHLR 486_ THTGE 491_ KPFQC 496_ HLCGK 501_ TFRTQ 506_ ASLDK 511_ HNRTH 516_ TGERP 521_ FSCEF 526_ CEQRF 531_ TEKGP 536_ LLRHV 541_ ASRHQ 546_ EGRPH 551_ FCQIC 556_ GKTFK 561_ AVEQL 566_ RVHVR 571_ RHKGV 576_ RKFEC 581_ TECGY 586_ KFTRQ 591_ AHLRR 596_ HMEIH 601_ DRVEN 606_ YNPRQ 611_ RKLRN 616_ LIIED 621_ EKMVV 626_ VALQP 631_ PAELE 636_ VGSAE 641_ VIVES 646_ LAQGG 651_ LASQL 656_ PGQRL 661_ CAEES 666_ FTGPG 671_ VLEPS 676_ LIITA 681_AVPED
1: Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length (PubMed:28082411, PubMed:28500257). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28082411, PubMed:28500257). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:24382891, PubMed:28500257, PubMed:7969177). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891). Acts as a transcription regulator of CIITA, the major factor regulating MHC class II gene expression (PubMed:39562739). In addition, regulates cellular m6A/m6Am methylation on RNA by facilitating the recruitment of the RNA demethylase, FTO, to target mRNAs (PubMed:39300486)