Ras-related protein Rap-2a (EC 3.6.5.2) (RbBP-30)
1_MREYK 6_ VVVLG 11_ SGGVG 16_ KSALT 21_ VQFVT 26_ GTFIE 31_ KYDPT 36_ IEDFY 41_ RKEIE 46_ VDSSP 51_ SVLEI 56_ LDTAG 61_ TEQFA 66_ SMRDL 71_ YIKNG 76_ QGFIL 81_ VYSLV 86_ NQQSF 91_ QDIKP 96_ MRDQI 101_ IRVKR 106_ YEKVP 111_ VILVG 116_ NKVDL 121_ ESERE 126_ VSSSE 131_ GRALA 136_ EEWGC 141_ PFMET 146_ SAKSK 151_ TMVDE 156_ LFAEI 161_ VRQMN 166_ YAAQP 171_ DKDDP 176_CCSAC
1: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form (PubMed:14966141, PubMed:15342639, PubMed:16246175, PubMed:16540189, PubMed:18930710, PubMed:20159449, PubMed:35293963). In its active form interacts with and regulates several effectors including MAP4K4, MINK1 and TNIK (PubMed:14966141, PubMed:15342639, PubMed:18930710, PubMed:20159449). Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development (PubMed:20159449). More generally, it is part of several signaling cascades and regulates cytoskeletal rearrangements, cell migration, cell adhesion and cell spreading (PubMed:14966141, PubMed:15342639, PubMed:16246175, PubMed:16540189, PubMed:18930710, PubMed:20159449, PubMed:35293963)