Serglycin (Hematopoietic proteoglycan core protein) (Platelet proteoglycan core protein) (P.PG) (Secretory granule proteoglycan core protein)
1_MMQKL 6_ LKCSR 11_ LVLAL 16_ ALILV 21_ LESSV 26_ QGYPT 31_ RRARY 36_ QWVRC 41_ NPDSN 46_ SANCL 51_ EEKGP 56_ MFELL 61_ PGESN 66_ KIPRL 71_ RTDLF 76_ PKTRI 81_ QDLNR 86_ IFPLS 91_ EDYSG 96_ SGFGS 101_ GSGSG 106_ SGSGS 111_ GFLTE 116_ MEQDY 121_ QLVDE 126_ SDAFH 131_ DNLRS 136_ LDRNL 141_ PSDSQ 146_ DLGQH 151_GLEED
1: Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF-alpha and may also regulate protease secretion. Inhibits bone mineralization