Granzyme B (EC 3.4.21.79) (C11) (CTLA-1) (Cathepsin G-like 1) (CTSGL1) (Cytotoxic T-lymphocyte proteinase 2) (Lymphocyte protease) (Fragmentin-2) (Granzyme-2) (Human lymphocyte protein) (HLP) (SECT) (T-cell serine protease 1-3E)
1_MQPIL 6_ LLLAF 11_ LLLPR 16_ ADAGE 21_ IIGGH 26_ EAKPH 31_ SRPYM 36_ AYLMI 41_ WDQKS 46_ LKRCG 51_ GFLIR 56_ DDFVL 61_ TAAHC 66_ WGSSI 71_ NVTLG 76_ AHNIK 81_ EQEPT 86_ QQFIP 91_ VKRPI 96_ PHPAY 101_ NPKNF 106_ SNDIM 111_ LLQLE 116_ RKAKR 121_ TRAVQ 126_ PLRLP 131_ SNKAQ 136_ VKPGQ 141_ TCSVA 146_ GWGQT 151_ APLGK 156_ HSHTL 161_ QEVKM 166_ TVQED 171_ RKCES 176_ DLRHY 181_ YDSTI 186_ ELCVG 191_ DPEIK 196_ KTSFK 201_ GDSGG 206_ PLVCN 211_ KVAQG 216_ IVSYG 221_ RNNGM 226_ PPRAC 231_ TKVSS 236_ FVHWI 241_KKTMK
1: Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:1985927, PubMed:3262682, PubMed:3263427). It cleaves after Asp (PubMed:1985927, PubMed:8258716). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death (PubMed:31953257, PubMed:32188940). Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -9 and -10 (CASP3, CASP9 and CASP10, respectively) to give rise to active enzymes mediating apoptosis (PubMed:9852092). Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (By similarity)