Androgen receptor (Dihydrotestosterone receptor) (Nuclear receptor subfamily 3 group C member 4)
1_MEVQL 6_ GLGRV 11_ YPRPP 16_ SKTYR 21_ GAFQN 26_ LFQSV 31_ REVIQ 36_ NPGPR 41_ HPEAA 46_ SAAPP 51_ GASLL 56_ LLQQQ 61_ QQQQQ 66_ QQQQQ 71_ QQQQQ 76_ QQQQQ 81_ ETSPR 86_ QQQQQ 91_ QGEDG 96_ SPQAH 101_ RRGPT 106_ GYLVL 111_ DEEQQ 116_ PSQPQ 121_ SALEC 126_ HPERG 131_ CVPEP 136_ GAAVA 141_ ASKGL 146_ PQQLP 151_ APPDE 156_ DDSAA 161_ PSTLS 166_ LLGPT 171_ FPGLS 176_ SCSAD 181_ LKDIL 186_ SEAST 191_ MQLLQ 196_ QQQQE 201_ AVSEG 206_ SSSGR 211_ AREAS 216_ GAPTS 221_ SKDNY 226_ LGGTS 231_ TISDN 236_ AKELC 241_ KAVSV 246_ SMGLG 251_ VEALE 256_ HLSPG 261_ EQLRG 266_ DCMYA 271_ PLLGV 276_ PPAVR 281_ PTPCA 286_ PLAEC 291_ KGSLL 296_ DDSAG 301_ KSTED 306_ TAEYS 311_ PFKGG 316_ YTKGL 321_ EGESL 326_ GCSGS 331_ AAAGS 336_ SGTLE 341_ LPSTL 346_ SLYKS 351_ GALDE 356_ AAAYQ 361_ SRDYY 366_ NFPLA 371_ LAGPP 376_ PPPPP 381_ PHPHA 386_ RIKLE 391_ NPLDY 396_ GSAWA 401_ AAAAQ 406_ CRYGD 411_ LASLH 416_ GAGAA 421_ GPGSG 426_ SPSAA 431_ ASSSW 436_ HTLFT 441_ AEEGQ 446_ LYGPC 451_ GGGGG 456_ GGGGG 461_ GGGGG 466_ GGGGG 471_ GGGEA 476_ GAVAP 481_ YGYTR 486_ PPQGL 491_ AGQES 496_ DFTAP 501_ DVWYP 506_ GGMVS 511_ RVPYP 516_ SPTCV 521_ KSEMG 526_ PWMDS 531_ YSGPY 536_ GDMRL 541_ ETARD 546_ HVLPI 551_ DYYFP 556_ PQKTC 561_ LICGD 566_ EASGC 571_ HYGAL 576_ TCGSC 581_ KVFFK 586_ RAAEG 591_ KQKYL 596_ CASRN 601_ DCTID 606_ KFRRK 611_ NCPSC 616_ RLRKC 621_ YEAGM 626_ TLGAR 631_ KLKKL 636_ GNLKL 641_ QEEGE 646_ ASSTT 651_ SPTEE 656_ TTQKL 661_ TVSHI 666_ EGYEC 671_ QPIFL 676_ NVLEA 681_ IEPGV 686_ VCAGH 691_ DNNQP 696_ DSFAA 701_ LLSSL 706_ NELGE 711_ RQLVH 716_ VVKWA 721_ KALPG 726_ FRNLH 731_ VDDQM 736_ AVIQY 741_ SWMGL 746_ MVFAM 751_ GWRSF 756_ TNVNS 761_ RMLYF 766_ APDLV 771_ FNEYR 776_ MHKSR 781_ MYSQC 786_ VRMRH 791_ LSQEF 796_ GWLQI 801_ TPQEF 806_ LCMKA 811_ LLLFS 816_ IIPVD 821_ GLKNQ 826_ KFFDE 831_ LRMNY 836_ IKELD 841_ RIIAC 846_ KRKNP 851_ TSCSR 856_ RFYQL 861_ TKLLD 866_ SVQPI 871_ ARELH 876_ QFTFD 881_ LLIKS 886_ HMVSV 891_ DFPEM 896_ MAEII 901_ SVQVP 906_ KILSG 911_KVKPI
1: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3
2: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones
3: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones