Retinoic acid receptor alpha (RAR-alpha) (Nuclear receptor subfamily 1 group B member 1)
1_MASNS 6_ SSCPT 11_ PGGGH 16_ LNGYP 21_ VPPYA 26_ FFFPP 31_ MLGGL 36_ SPPGA 41_ LTTLQ 46_ HQLPV 51_ SGYST 56_ PSPAT 61_ IETQS 66_ SSSEE 71_ IVPSP 76_ PSPPP 81_ LPRIY 86_ KPCFV 91_ CQDKS 96_ SGYHY 101_ GVSAC 106_ EGCKG 111_ FFRRS 116_ IQKNM 121_ VYTCH 126_ RDKNC 131_ IINKV 136_ TRNRC 141_ QYCRL 146_ QKCFE 151_ VGMSK 156_ ESVRN 161_ DRNKK 166_ KKEVP 171_ KPECS 176_ ESYTL 181_ TPEVG 186_ ELIEK 191_ VRKAH 196_ QETFP 201_ ALCQL 206_ GKYTT 211_ NNSSE 216_ QRVSL 221_ DIDLW 226_ DKFSE 231_ LSTKC 236_ IIKTV 241_ EFAKQ 246_ LPGFT 251_ TLTIA 256_ DQITL 261_ LKAAC 266_ LDILI 271_ LRICT 276_ RYTPE 281_ QDTMT 286_ FSDGL 291_ TLNRT 296_ QMHNA 301_ GFGPL 306_ TDLVF 311_ AFANQ 316_ LLPLE 321_ MDDAE 326_ TGLLS 331_ AICLI 336_ CGDRQ 341_ DLEQP 346_ DRVDM 351_ LQEPL 356_ LEALK 361_ VYVRK 366_ RRPSR 371_ PHMFP 376_ KMLMK 381_ ITDLR 386_ SISAK 391_ GAERV 396_ ITLKM 401_ EIPGS 406_ MPPLI 411_ QEMLE 416_ NSEGL 421_ DTLSG 426_ QPGGG 431_ GRDGG 436_ GLAPP 441_ PGSCS 446_ PSLSP 451_ SSNRS 456_SPATH
1: Receptor for retinoic acid (PubMed:16417524, PubMed:19850744, PubMed:20215566, PubMed:21152046, PubMed:37478846). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes (PubMed:21152046, PubMed:28167758, PubMed:37478846). The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 (PubMed:19398580, PubMed:28167758). In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone deacetylation, chromatin condensation and transcriptional suppression (PubMed:16417524). On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation (PubMed:19850744, PubMed:20215566, PubMed:37478846, PubMed:9267036). Formation of a complex with histone deacetylases might lead to inhibition of RARE DNA element binding and to transcriptional repression (PubMed:28167758). Transcriptional activation and RARE DNA element binding might be supported by the transcription factor KLF2 (PubMed:28167758). RARA plays an essential role in the regulation of retinoic acid-induced germ cell development during spermatogenesis (By similarity). Has a role in the survival of early spermatocytes at the beginning prophase of meiosis (By similarity). In Sertoli cells, may promote the survival and development of early meiotic prophase spermatocytes (By similarity). In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity). Together with RXRA, positively regulates microRNA-10a expression, thereby inhibiting the GATA6/VCAM1 signaling response to pulsatile shear stress in vascular endothelial cells (PubMed:28167758). In association with HDAC3, HDAC5 and HDAC7 corepressors, plays a role in the repression of microRNA-10a and thereby promotes the inflammatory response (PubMed:28167758)