Apoptosis regulator Bcl-2
1_MAHAG 6_ RTGYD 11_ NREIV 16_ MKYIH 21_ YKLSQ 26_ RGYEW 31_ DAGDV 36_ GAAPP 41_ GAAPA 46_ PGIFS 51_ SQPGH 56_ TPHPA 61_ ASRDP 66_ VARTS 71_ PLQTP 76_ AAPGA 81_ AAGPA 86_ LSPVP 91_ PVVHL 96_ TLRQA 101_ GDDFS 106_ RRYRR 111_ DFAEM 116_ SSQLH 121_ LTPFT 126_ ARGRF 131_ ATVVE 136_ ELFRD 141_ GVNWG 146_ RIVAF 151_ FEFGG 156_ VMCVE 161_ SVNRE 166_ MSPLV 171_ DNIAL 176_ WMTEY 181_ LNRHL 186_ HTWIQ 191_ DNGGW 196_ DAFVE 201_ LYGPS 206_ MRPLF 211_ DFSWL 216_ SLKTL 221_ LSLAL 226_ VGACI 231_TLGAY
1: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells (PubMed:1508712, PubMed:8183370). Regulates cell death by controlling the mitochondrial membrane permeability (PubMed:11368354). Appears to function in a feedback loop system with caspases (PubMed:11368354). Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PubMed:11368354). Also acts as an inhibitor of autophagy: interacts with BECN1 and AMBRA1 during non-starvation conditions and inhibits their autophagy function (PubMed:18570871, PubMed:20889974, PubMed:21358617). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785)