Nuclear receptor subfamily 2 group F member 6 (V-erbA-related protein 2) (EAR-2)
1_MAMVT 6_ GGWGG 11_ PGGDT 16_ NGVDK 21_ AGGYP 26_ RAAED 31_ DSASP 36_ PGAAS 41_ DAEPG 46_ DEERP 51_ GLQVD 56_ CVVCG 61_ DKSSG 66_ KHYGV 71_ FTCEG 76_ CKSFF 81_ KRSIR 86_ RNLSY 91_ TCRSN 96_ RDCQI 101_ DQHHR 106_ NQCQY 111_ CRLKK 116_ CFRVG 121_ MRKEA 126_ VQRGR 131_ IPHSL 136_ PGAVA 141_ ASSGS 146_ PPGSA 151_ LAAVA 156_ SGGDL 161_ FPGQP 166_ VSELI 171_ AQLLR 176_ AEPYP 181_ AAAGR 186_ FGAGG 191_ GAAGA 196_ VLGID 201_ NVCEL 206_ AARLL 211_ FSTVE 216_ WARHA 221_ PFFPE 226_ LPVAD 231_ QVALL 236_ RLSWS 241_ ELFVL 246_ NAAQA 251_ ALPLH 256_ TAPLL 261_ AAAGL 266_ HAAPM 271_ AAERA 276_ VAFMD 281_ QVRAF 286_ QEQVD 291_ KLGRL 296_ QVDSA 301_ EYGCL 306_ KAIAL 311_ FTPDA 316_ CGLSD 321_ PAHVE 326_ SLQEK 331_ AQVAL 336_ TEYVR 341_ AQYPS 346_ QPQRF 351_ GRLLL 356_ RLPAL 361_ RAVPA 366_ SLISQ 371_ LFFMR 376_ LVGKT 381_ PIETL 386_ IRDML 391_ LSGST 396_FNWPY
1: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC)