Thioredoxin (Trx) (ATL-derived factor) (ADF) (Surface-associated sulphydryl protein) (SASP) (allergen Hom s Trx)
1_MVKQI 6_ ESKTA 11_ FQEAL 16_ DAAGD 21_ KLVVV 26_ DFSAT 31_ WCGPC 36_ KMIKP 41_ FFHSL 46_ SEKYS 51_ NVIFL 56_ EVDVD 61_ DCQDV 66_ ASECE 71_ VKCMP 76_ TFQFF 81_ KKGQK 86_ VGEFS 91_ GANKE 96_KLEAT
1: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:17182577, PubMed:19032234, PubMed:2176490). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity (PubMed:16408020, PubMed:17606900). Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (PubMed:11118054, PubMed:9108029)
2: ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55)