Transforming growth factor beta-3 proprotein [Cleaved into: Latency-associated peptide (LAP); Transforming growth factor beta-3 (TGF-beta-3)]
1_MKMHL 6_ QRALV 11_ VLALL 16_ NFATV 21_ SLSLS 26_ TCTTL 31_ DFGHI 36_ KKKRV 41_ EAIRG 46_ QILSK 51_ LRLTS 56_ PPEPT 61_ VMTHV 66_ PYQVL 71_ ALYNS 76_ TRELL 81_ EEMHG 86_ EREEG 91_ CTQEN 96_ TESEY 101_ YAKEI 106_ HKFDM 111_ IQGLA 116_ EHNEL 121_ AVCPK 126_ GITSK 131_ VFRFN 136_ VSSVE 141_ KNRTN 146_ LFRAE 151_ FRVLR 156_ VPNPS 161_ SKRNE 166_ QRIEL 171_ FQILR 176_ PDEHI 181_ AKQRY 186_ IGGKN 191_ LPTRG 196_ TAEWL 201_ SFDVT 206_ DTVRE 211_ WLLRR 216_ ESNLG 221_ LEISI 226_ HCPCH 231_ TFQPN 236_ GDILE 241_ NIHEV 246_ MEIKF 251_ KGVDN 256_ EDDHG 261_ RGDLG 266_ RLKKQ 271_ KDHHN 276_ PHLIL 281_ MMIPP 286_ HRLDN 291_ PGQGG 296_ QRKKR 301_ ALDTN 306_ YCFRN 311_ LEENC 316_ CVRPL 321_ YIDFR 326_ QDLGW 331_ KWVHE 336_ PKGYY 341_ ANFCS 346_ GPCPY 351_ LRSAD 356_ TTHST 361_ VLGLY 366_ NTLNP 371_ EASAS 376_ PCCVP 381_ QDLEP 386_ LTILY 391_ YVGRT 396_ PKVEQ 401_ LSNMV 406_VKSCK
1: Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively
2: Required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix (By similarity). Associates non-covalently with TGF-beta-3 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-3 (By similarity). Interaction with integrins results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-3 (By similarity)
3: Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains remain non-covalently linked rendering TGF-beta-3 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP that control activation of TGF-beta-3 and maintain it in a latent state during storage in extracellular milieus (By similarity). TGF-beta-3 is released from LAP by integrins: integrin-binding results in distortion of the LAP chain and subsequent release of the active TGF-beta-3 (By similarity). Once activated following release of LAP, TGF-beta-3 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity)