Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase)
1_MEPFV 6_ VLVLC 11_ LSFML 16_ LFSLW 21_ RQSCR 26_ RRKLP 31_ PGPTP 36_ LPIIG 41_ NMLQI 46_ DVKDI 51_ CKSFT 56_ NFSKV 61_ YGPVF 66_ TVYFG 71_ MNPIV 76_ VFHGY 81_ EAVKE 86_ ALIDN 91_ GEEFS 96_ GRGNS 101_ PISQR 106_ ITKGL 111_ GIISS 116_ NGKRW 121_ KEIRR 126_ FSLTT 131_ LRNFG 136_ MGKRS 141_ IEDRV 146_ QEEAH 151_ CLVEE 156_ LRKTK 161_ ASPCD 166_ PTFIL 171_ GCAPC 176_ NVICS 181_ VVFQK 186_ RFDYK 191_ DQNFL 196_ TLMKR 201_ FNENF 206_ RILNS 211_ PWIQV 216_ CNNFP 221_ LLIDC 226_ FPGTH 231_ NKVLK 236_ NVALT 241_ RSYIR 246_ EKVKE 251_ HQASL 256_ DVNNP 261_ RDFID 266_ CFLIK 271_ MEQEK 276_ DNQKS 281_ EFNIE 286_ NLVGT 291_ VADLF 296_ VAGTE 301_ TTSTT 306_ LRYGL 311_ LLLLK 316_ HPEVT 321_ AKVQE 326_ EIDHV 331_ IGRHR 336_ SPCMQ 341_ DRSHM 346_ PYTDA 351_ VVHEI 356_ QRYSD 361_ LVPTG 366_ VPHAV 371_ TTDTK 376_ FRNYL 381_ IPKGT 386_ TIMAL 391_ LTSVL 396_ HDDKE 401_ FPNPN 406_ IFDPG 411_ HFLDK 416_ NGNFK 421_ KSDYF 426_ MPFSA 431_ GKRIC 436_ AGEGL 441_ ARMEL 446_ FLFLT 451_ TILQN 456_ FNLKS 461_ VDDLK 466_ NLNTT 471_ AVTKG 476_ IVSLP 481_PSYQI
1: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576, PubMed:7574697). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576, PubMed:7574697). Primarily catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond (PubMed:15766564, PubMed:19965576, PubMed:7574697). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes all trans-retinoic acid toward its 4-hydroxylated form (PubMed:11093772). Displays 16-alpha hydroxylase activity toward estrogen steroid hormones, 17beta-estradiol (E2) and estrone (E1) (PubMed:14559847). Plays a role in the oxidative metabolism of xenobiotics. It is the principal enzyme responsible for the metabolism of the anti-cancer drug paclitaxel (taxol) (PubMed:26427316)