Cytochrome P450 2D6 (EC 1.14.14.-) (CYPIID6) (Cholesterol 25-hydroxylase) (Cytochrome P450-DB1) (Debrisoquine 4-hydroxylase)
1_MGLEA 6_ LVPLA 11_ VIVAI 16_ FLLLV 21_ DLMHR 26_ RQRWA 31_ ARYPP 36_ GPLPL 41_ PGLGN 46_ LLHVD 51_ FQNTP 56_ YCFDQ 61_ LRRRF 66_ GDVFS 71_ LQLAW 76_ TPVVV 81_ LNGLA 86_ AVREA 91_ LVTHG 96_ EDTAD 101_ RPPVP 106_ ITQIL 111_ GFGPR 116_ SQGVF 121_ LARYG 126_ PAWRE 131_ QRRFS 136_ VSTLR 141_ NLGLG 146_ KKSLE 151_ QWVTE 156_ EAACL 161_ CAAFA 166_ NHSGR 171_ PFRPN 176_ GLLDK 181_ AVSNV 186_ IASLT 191_ CGRRF 196_ EYDDP 201_ RFLRL 206_ LDLAQ 211_ EGLKE 216_ ESGFL 221_ REVLN 226_ AVPVL 231_ LHIPA 236_ LAGKV 241_ LRFQK 246_ AFLTQ 251_ LDELL 256_ TEHRM 261_ TWDPA 266_ QPPRD 271_ LTEAF 276_ LAEME 281_ KAKGN 286_ PESSF 291_ NDENL 296_ RIVVA 301_ DLFSA 306_ GMVTT 311_ STTLA 316_ WGLLL 321_ MILHP 326_ DVQRR 331_ VQQEI 336_ DDVIG 341_ QVRRP 346_ EMGDQ 351_ AHMPY 356_ TTAVI 361_ HEVQR 366_ FGDIV 371_ PLGVT 376_ HMTSR 381_ DIEVQ 386_ GFRIP 391_ KGTTL 396_ ITNLS 401_ SVLKD 406_ EAVWE 411_ KPFRF 416_ HPEHF 421_ LDAQG 426_ HFVKP 431_ EAFLP 436_ FSAGR 441_ RACLG 446_ EPLAR 451_ MELFL 456_ FFTSL 461_ LQHFS 466_ FSVPT 471_ GQPRP 476_ SHHGV 481_ FAFLV 486_ SPSPY 491_ELCAV
1: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:19965576, PubMed:20972997). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:18698000, PubMed:21289075). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). Catalyzes the oxidative transformations of all-trans retinol to all-trans retinal, a precursor for the active form all-trans-retinoic acid (PubMed:10681376). Also involved in the oxidative metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants