Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
1_MAEPR 6_ QEFEV 11_ MEDHA 16_ GTYGL 21_ GDRKD 26_ QGGYT 31_ MHQDQ 36_ EGDTD 41_ AGLKE 46_ SPLQT 51_ PTEDG 56_ SEEPG 61_ SETSD 66_ AKSTP 71_ TAEDV 76_ TAPLV 81_ DEGAP 86_ GKQAA 91_ AQPHT 96_ EIPEG 101_ TTAEE 106_ AGIGD 111_ TPSLE 116_ DEAAG 121_ HVTQE 126_ PESGK 131_ VVQEG 136_ FLREP 141_ GPPGL 146_ SHQLM 151_ SGMPG 156_ APLLP 161_ EGPRE 166_ ATRQP 171_ SGTGP 176_ EDTEG 181_ GRHAP 186_ ELLKH 191_ QLLGD 196_ LHQEG 201_ PPLKG 206_ AGGKE 211_ RPGSK 216_ EEVDE 221_ DRDVD 226_ ESSPQ 231_ DSPPS 236_ KASPA 241_ QDGRP 246_ PQTAA 251_ REATS 256_ IPGFP 261_ AEGAI 266_ PLPVD 271_ FLSKV 276_ STEIP 281_ ASEPD 286_ GPSVG 291_ RAKGQ 296_ DAPLE 301_ FTFHV 306_ EITPN 311_ VQKEQ 316_ AHSEE 321_ HLGRA 326_ AFPGA 331_ PGEGP 336_ EARGP 341_ SLGED 346_ TKEAD 351_ LPEPS 356_ EKQPA 361_ AAPRG 366_ KPVSR 371_ VPQLK 376_ ARMVS 381_ KSKDG 386_ TGSDD 391_ KKAKT 396_ STRSS 401_ AKTLK 406_ NRPCL 411_ SPKHP 416_ TPGSS 421_ DPLIQ 426_ PSSPA 431_ VCPEP 436_ PSSPK 441_ YVSSV 446_ TSRTG 451_ SSGAK 456_ EMKLK 461_ GADGK 466_ TKIAT 471_ PRGAA 476_ PPGQK 481_ GQANA 486_ TRIPA 491_ KTPPA 496_ PKTPP 501_ SSGEP 506_ PKSGD 511_ RSGYS 516_ SPGSP 521_ GTPGS 526_ RSRTP 531_ SLPTP 536_ PTREP 541_ KKVAV 546_ VRTPP 551_ KSPSS 556_ AKSRL 561_ QTAPV 566_ PMPDL 571_ KNVKS 576_ KIGST 581_ ENLKH 586_ QPGGG 591_ KVQII 596_ NKKLD 601_ LSNVQ 606_ SKCGS 611_ KDNIK 616_ HVPGG 621_ GSVQI 626_ VYKPV 631_ DLSKV 636_ TSKCG 641_ SLGNI 646_ HHKPG 651_ GGQVE 656_ VKSEK 661_ LDFKD 666_ RVQSK 671_ IGSLD 676_ NITHV 681_ PGGGN 686_ KKIET 691_ HKLTF 696_ RENAK 701_ AKTDH 706_ GAEIV 711_ YKSPV 716_ VSGDT 721_ SPRHL 726_ SNVSS 731_ TGSID 736_ MVDSP 741_ QLATL 746_ ADEVS 751_ASLAK
1: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization