Complement component C7
1_MKVIS 6_ LFILV 11_ GFIGE 16_ FQSFS 21_ SASSP 26_ VNCQW 31_ DFYAP 36_ WSECN 41_ GCTKT 46_ QTRRR 51_ SVAVY 56_ GQYGG 61_ QPCVG 66_ NAFET 71_ QSCEP 76_ TRGCP 81_ TEEGC 86_ GERFR 91_ CFSGQ 96_ CISKS 101_ LVCNG 106_ DSDCD 111_ EDSAD 116_ EDRCE 121_ DSERR 126_ PSCDI 131_ DKPPP 136_ NIELT 141_ GNGYN 146_ ELTGQ 151_ FRNRV 156_ INTKS 161_ FGGQC 166_ RKVFS 171_ GDGKD 176_ FYRLS 181_ GNVLS 186_ YTFQV 191_ KINND 196_ FNYEF 201_ YNSTW 206_ SYVKH 211_ TSTEH 216_ TSSSR 221_ KRSFF 226_ RSSSS 231_ SSRSY 236_ TSHTN 241_ EIHKG 246_ KSYQL 251_ LVVEN 256_ TVEVA 261_ QFINN 266_ NPEFL 271_ QLAEP 276_ FWKEL 281_ SHLPS 286_ LYDYS 291_ AYRRL 296_ IDQYG 301_ THYLQ 306_ SGSLG 311_ GEYRV 316_ LFYVD 321_ SEKLK 326_ QNDFN 331_ SVEEK 336_ KCKSS 341_ GWHFV 346_ VKFSS 351_ HGCKE 356_ LENAL 361_ KAASG 366_ TQNNV 371_ LRGEP 376_ FIRGG 381_ GAGFI 386_ SGLSY 391_ LELDN 396_ PAGNK 401_ RRYSA 406_ WAESV 411_ TNLPQ 416_ VIKQK 421_ LTPLY 426_ ELVKE 431_ VPCAS 436_ VKKLY 441_ LKWAL 446_ EEYLD 451_ EFDPC 456_ HCRPC 461_ QNGGL 466_ ATVEG 471_ THCLC 476_ HCKPY 481_ TFGAA 486_ CEQGV 491_ LVGNQ 496_ AGGVD 501_ GGWSC 506_ WSSWS 511_ PCVQG 516_ KKTRS 521_ RECNN 526_ PPPSG 531_ GGRSC 536_ VGETT 541_ ESTQC 546_ EDEEL 551_ EHLRL 556_ LEPHC 561_ FPLSL 566_ VPTEF 571_ CPSPP 576_ ALKDG 581_ FVQDE 586_ GTMFP 591_ VGKNV 596_ VYTCN 601_ EGYSL 606_ IGNPV 611_ ARCGE 616_ DLRWL 621_ VGEMH 626_ CQKIA 631_ CVLPV 636_ LMDGI 641_ QSHPQ 646_ KPFYT 651_ VGEKV 656_ TVSCS 661_ GGMSL 666_ EGPSA 671_ FLCGS 676_ SLKWS 681_ PEMKN 686_ ARCVQ 691_ KENPL 696_ TQAVP 701_ KCQRW 706_ EKLQN 711_ SRCVC 716_ KMPYE 721_ CGPSL 726_ DVCAQ 731_ DERSK 736_ RILPL 741_ TVCKM 746_ HVLHC 751_ QGRNY 756_ TLTGR 761_ DSCTL 766_ PASAE 771_ KACGA 776_ CPLWG 781_ KCDAE 786_ SSKCV 791_ CREAS 796_ ECEEE 801_ GFSIC 806_ VEVNG 811_ KEQTM 816_ SECEA 821_ GALRC 826_ RGQSI 831_ SVTSI 836_RPCAA
1: Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22832194, PubMed:26841837, PubMed:27052168, PubMed:30552328, PubMed:3335508). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:22832194, PubMed:30552328, PubMed:3335508). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:22832194, PubMed:30552328, PubMed:3335508). C7 serves as a membrane anchor (PubMed:30552328). During MAC assembly, associates with C5b and C6 to form the C5b-7 complex, a key lipophilic precursor of the MAC complex, which associates with the outer leaflet and reduces the energy for membrane bending (PubMed:30552328, PubMed:32569291)