Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
1_MRGAR 6_ GAWDF 11_ LCVLL 16_ LLLRV 21_ QTGSS 26_ QPSVS 31_ PGEPS 36_ PPSIH 41_ PGKSD 46_ LIVRV 51_ GDEIR 56_ LLCTD 61_ PGFVK 66_ WTFEI 71_ LDETN 76_ ENKQN 81_ EWITE 86_ KAEAT 91_ NTGKY 96_ TCTNK 101_ HGLSN 106_ SIYVF 111_ VRDPA 116_ KLFLV 121_ DRSLY 126_ GKEDN 131_ DTLVR 136_ CPLTD 141_ PEVTN 146_ YSLKG 151_ CQGKP 156_ LPKDL 161_ RFIPD 166_ PKAGI 171_ MIKSV 176_ KRAYH 181_ RLCLH 186_ CSVDQ 191_ EGKSV 196_ LSEKF 201_ ILKVR 206_ PAFKA 211_ VPVVS 216_ VSKAS 221_ YLLRE 226_ GEEFT 231_ VTCTI 236_ KDVSS 241_ SVYST 246_ WKREN 251_ SQTKL 256_ QEKYN 261_ SWHHG 266_ DFNYE 271_ RQATL 276_ TISSA 281_ RVNDS 286_ GVFMC 291_ YANNT 296_ FGSAN 301_ VTTTL 306_ EVVDK 311_ GFINI 316_ FPMIN 321_ TTVFV 326_ NDGEN 331_ VDLIV 336_ EYEAF 341_ PKPEH 346_ QQWIY 351_ MNRTF 356_ TDKWE 361_ DYPKS 366_ ENESN 371_ IRYVS 376_ ELHLT 381_ RLKGT 386_ EGGTY 391_ TFLVS 396_ NSDVN 401_ AAIAF 406_ NVYVN 411_ TKPEI 416_ LTYDR 421_ LVNGM 426_ LQCVA 431_ AGFPE 436_ PTIDW 441_ YFCPG 446_ TEQRC 451_ SASVL 456_ PVDVQ 461_ TLNSS 466_ GPPFG 471_ KLVVQ 476_ SSIDS 481_ SAFKH 486_ NGTVE 491_ CKAYN 496_ DVGKT 501_ SAYFN 506_ FAFKG 511_ NNKEQ 516_ IHPHT 521_ LFTPL 526_ LIGFV 531_ IVAGM 536_ MCIIV 541_ MILTY 546_ KYLQK 551_ PMYEV 556_ QWKVV 561_ EEING 566_ NNYVY 571_ IDPTQ 576_ LPYDH 581_ KWEFP 586_ RNRLS 591_ FGKTL 596_ GAGAF 601_ GKVVE 606_ ATAYG 611_ LIKSD 616_ AAMTV 621_ AVKML 626_ KPSAH 631_ LTERE 636_ ALMSE 641_ LKVLS 646_ YLGNH 651_ MNIVN 656_ LLGAC 661_ TIGGP 666_ TLVIT 671_ EYCCY 676_ GDLLN 681_ FLRRK 686_ RDSFI 691_ CSKQE 696_ DHAEA 701_ ALYKN 706_ LLHSK 711_ ESSCS 716_ DSTNE 721_ YMDMK 726_ PGVSY 731_ VVPTK 736_ ADKRR 741_ SVRIG 746_ SYIER 751_ DVTPA 756_ IMEDD 761_ ELALD 766_ LEDLL 771_ SFSYQ 776_ VAKGM 781_ AFLAS 786_ KNCIH 791_ RDLAA 796_ RNILL 801_ THGRI 806_ TKICD 811_ FGLAR 816_ DIKND 821_ SNYVV 826_ KGNAR 831_ LPVKW 836_ MAPES 841_ IFNCV 846_ YTFES 851_ DVWSY 856_ GIFLW 861_ ELFSL 866_ GSSPY 871_ PGMPV 876_ DSKFY 881_ KMIKE 886_ GFRML 891_ SPEHA 896_ PAEMY 901_ DIMKT 906_ CWDAD 911_ PLKRP 916_ TFKQI 921_ VQLIE 926_ KQISE 931_ STNHI 936_ YSNLA 941_ NCSPN 946_ RQKPV 951_ VDHSV 956_ RINSV 961_ GSTAS 966_ SSQPL 971_LVHDD
1: Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1